Iron, hepcidin, and the metal connection. - Université de Rennes Access content directly
Journal Articles Frontiers in Pharmacology Year : 2013

Iron, hepcidin, and the metal connection.

Abstract

Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases. However, from both experimental data and clinical findings, "iron-related proteins" appear to also be involved in the metabolism of other metals, especially divalent cations. Reports have demonstrated that some metals may affect, directly or indirectly, the expression of proteins involved in iron metabolism. Throughout their lives, individuals are exposed to various metals during personal and/or occupational activities. Therefore, better knowledge of the connections between iron and other metals could improve our understanding of iron-related diseases, especially the variability in phenotypic expression, as well as a variety of diseases in which iron metabolism is secondarily affected. Controlling the metabolism of other metals could represent a promising innovative therapeutic approach.

Dates and versions

hal-01128096 , version 1 (09-03-2015)

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Olivier Loréal, Thibault Cavey, Edouard Bardou-Jacquet, Pascal Guggenbuhl, Martine Ropert, et al.. Iron, hepcidin, and the metal connection.. Frontiers in Pharmacology, 2013, 5, pp.128. ⟨10.3389/fphar.2014.00128⟩. ⟨hal-01128096⟩
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