α-Hydroxyallylsilanes as Propionaldehyde Enolate Equivalents and Their Use toward Iterative Aldol Reactions - Université de Rennes Access content directly
Journal Articles Journal of Organic Chemistry Year : 2015

α-Hydroxyallylsilanes as Propionaldehyde Enolate Equivalents and Their Use toward Iterative Aldol Reactions

Abstract

Smooth and efficient reaction conditions have been found for the transformation of protected β-hydroxyacylsilanes into the corresponding aldehydes. This opens a new route to iterative aldol reactions, and it has been used for the synthesis of fragments of several bioactive natural products.
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hal-01116172 , version 1 (12-02-2015)

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Johal Ruiz, Akondi Srirama Murthy, Thierry Roisnel, Srivari Chandrasekhar, René Grée. α-Hydroxyallylsilanes as Propionaldehyde Enolate Equivalents and Their Use toward Iterative Aldol Reactions. Journal of Organic Chemistry, 2015, 80 (4), pp.2364-2375. ⟨10.1021/acs.joc.5b00031⟩. ⟨hal-01116172⟩
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