Weak interactions in clobazam-lactose mixtures examined by differential scanning calorimetry: Comparison with the captopril-lactose system. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Thermochimica Acta Année : 2012

Weak interactions in clobazam-lactose mixtures examined by differential scanning calorimetry: Comparison with the captopril-lactose system.

L Cornevin
  • Fonction : Auteur
G Burgot
  • Fonction : Auteur

Résumé

The thermal behavior of binary mixts. of 2 drugs (clobazam and captopril, resp.) and a pharmaceutical excipient (lactose monohydrate) was measured with differential scanning calorimetry to det. thermodn. and kinetic parameters (dehydration and melting enthalpies and dehydration and glass-transition activation energies) which might be affected by intermol. interactions. A kinetic study showed that lactose dehydration is not a single-step conversion and that clobazam contributed to reduce the energy barrier for the bulk dehydration of the excipient. On the other hand, the phys. interactions between metastable liq. clobazam and cryst. anhyd. α-lactose obtained from monohydrate dehydration gave rise to the recrystn. of clobazam. In the captopril-lactose system, the liq. captopril influenced the lactose dehydration: a sharp increase of the dehydration enthalpy and a concurrent redn. of the dehydration temp. were obsd. Finally, it turned out that solid-phase transitions were enhanced by the contact with a liq. phase. [on SciFinder(R)]

Domaines

Autre

Dates et versions

hal-01070080 , version 1 (30-09-2014)

Identifiants

Citer

S. Toscani, L Cornevin, G Burgot. Weak interactions in clobazam-lactose mixtures examined by differential scanning calorimetry: Comparison with the captopril-lactose system.. Thermochimica Acta, 2012, 543, pp.197--204. ⟨10.1016/j.tca.2012.05.011⟩. ⟨hal-01070080⟩
50 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More