Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy. - Université de Rennes Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Year : 2013

Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.

Abstract

We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality.

Domains

Catalysis

Dates and versions

hal-00878575 , version 1 (30-10-2013)

Identifiers

Cite

Guillaume Garcia, Fabien Hammerer, Florent Poyer, Sylvain Achelle, Marie-Paule Teulade-Fichou, et al.. Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.. Bioorganic and Medicinal Chemistry, 2013, 21 (1), pp.153-65. ⟨10.1016/j.bmc.2012.10.042⟩. ⟨hal-00878575⟩
88 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More