Palladium-catalysed direct arylation of heteroaromatics using free-NH2 iodoanilines with inhibition of amination reaction
Résumé
The palladium-catalysed direct arylation of heteroaromatics with unprotected iodoanilines proceeds in moderate to high yields using only 1 mol% Pd(OAc)2 as the catalyst and potassium acetate as the base. No amination reaction was observed under these conditions. A wide variety of heteroarenes have been successfully employed.