Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Letters in Organic Chemistry Année : 2010

Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation

Résumé

An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a one-pot three-component cyclocondensation reaction of an aromatic aldehyde, β-ketoester, and urea or thiourea under solvent-free conditions using triethylamine (Et3N) as catalyst for the Biginelli reaction.
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Dates et versions

hal-00869753 , version 1 (04-10-2013)

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Abdelmadjid Debache, Wassima Ghalem, Raouf Boulcina, Ali Belfaitah, Salah Rhouati, et al.. Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation. Letters in Organic Chemistry, 2010, 7 (5), pp.272-276. ⟨10.2174/10272⟩. ⟨hal-00869753⟩
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