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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2012

Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity.

Vemula Praveen Kumar
  • Fonction : Auteur
R. Gajendra Reddy
  • Fonction : Auteur
Duc Duy Vo
  • Fonction : Auteur
Sumana Chakravarty
  • Fonction : Auteur
Srivari Chandrasekhar
  • Fonction : Auteur

Résumé

A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity.

Dates et versions

hal-00841545 , version 1 (05-07-2013)

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Citer

Vemula Praveen Kumar, R. Gajendra Reddy, Duc Duy Vo, Sumana Chakravarty, Srivari Chandrasekhar, et al.. Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity.. Bioorganic and Medicinal Chemistry Letters, 2012, 22 (3), pp.1439-44. ⟨10.1016/j.bmcl.2011.12.015⟩. ⟨hal-00841545⟩
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