A general cyclocarbonylation of aryl bromides and triflates with acetylenes: palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2011

A general cyclocarbonylation of aryl bromides and triflates with acetylenes: palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones.

Résumé

Making use of CO: An improved efficient synthesis of 5-aryl-3-alkylidenefuran-2-ones has been developed (see scheme). Starting from readily available (hetero)aryl bromides or aryl triflates and alkynes, furanones were produced in good yields through a double carbonylation process. To illustrate the generality of the method more than 25 furanone derivatives were synthesized, including the permethylated kinase inhibitor BE-23372M.

Domaines

Catalyse

Dates et versions

hal-00652012 , version 1 (14-12-2011)

Identifiants

Citer

Xiao-Feng Wu, Basker Sundararaju, Pazhamalai Anbarasan, Helfried Neumann, Pierre H. Dixneuf, et al.. A general cyclocarbonylation of aryl bromides and triflates with acetylenes: palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones.. Chemistry - A European Journal, 2011, 17 (29), pp.8014-7. ⟨10.1002/chem.201101083⟩. ⟨hal-00652012⟩
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