A general cyclocarbonylation of aryl bromides and triflates with acetylenes: palladium-catalyzed synthesis of 3-alkylidenefuran-2-ones.
Résumé
Making use of CO: An improved efficient synthesis of 5-aryl-3-alkylidenefuran-2-ones has been developed (see scheme). Starting from readily available (hetero)aryl bromides or aryl triflates and alkynes, furanones were produced in good yields through a double carbonylation process. To illustrate the generality of the method more than 25 furanone derivatives were synthesized, including the permethylated kinase inhibitor BE-23372M.