Independent predictors of metachronous bladder transitional cell carcinoma (TCC) after nephroureterectomy for TCC of the upper urinary tract. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue BJU International Année : 2008

Independent predictors of metachronous bladder transitional cell carcinoma (TCC) after nephroureterectomy for TCC of the upper urinary tract.

Giacomo Novara
  • Fonction : Auteur
Vincenzo de Marco
  • Fonction : Auteur
Orietta Dalpiaz
  • Fonction : Auteur
Fedra Gottardo
  • Fonction : Auteur
Vianney Bouygues
  • Fonction : Auteur
Antonio Galfano
  • Fonction : Auteur
Guido Martignoni
  • Fonction : Auteur
Walter Artibani
  • Fonction : Auteur
Vincenzo Ficarra
  • Fonction : Auteur

Résumé

OBJECTIVE: To identify the prognostic factors predictive of metachronous bladder transitional cell carcinoma (TCC) in a multi-institutional dataset of patients who had undergone nephroureterectomy (NU) for nonmetastatic upper urinary tract (UUT) TCC. PATIENTS AND METHODS: The clinical and pathological data of 231 patients who had had NU for UUT-TCC from 1989 to 2005 in three European centres were collected retrospectively, and analysed for clinical and pathological variables. RESULTS: The median follow-up was 38 months; during the follow-up, bladder TCC was detected in 109 patients (47.2%), and was significantly more common in patients who had UUT-TCC after previous bladder TCC (P < 0.001), in those with ureteric cancer (P = 0.022), and in those with pT2 UUT-TCC (P = 0.017). On multivariate analysis, a previous history of bladder TCC was the only independent predictor of metachronous bladder TCC (hazard ratio 2.825; P < 0.001). The 5-year probability of being free from metachronous bladder TCC was 45.5%. A history of bladder TCC (P < 0.001) and UUT tumour site (P = 0.01) were significantly associated with the probability of bladder recurrence-free survival. On multivariate analyses, a previous history of bladder TCC (hazard ratio 2.226; P < 0.001) and the presence of ureteric TCC (1.562; P = 0.036) were independent predictors of the probabilities of being free from metachronous bladder TCC. CONCLUSION: In this multi-institutional study of patients who had had NU for UUT-TCC, a history of bladder TCC was the only independent predictor of metachronous bladder TCC, while both a history of bladder TCC and the presence of ureteric tumours were predictive of the probabilities of being free from metachronous bladder TCC.
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Dates et versions

hal-00277248 , version 1 (05-05-2008)

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Giacomo Novara, Vincenzo de Marco, Orietta Dalpiaz, Fedra Gottardo, Vianney Bouygues, et al.. Independent predictors of metachronous bladder transitional cell carcinoma (TCC) after nephroureterectomy for TCC of the upper urinary tract.. BJU International, 2008, 101 (11), pp.1368-74. ⟨10.1111/j.1464-410X.2008.07438.x⟩. ⟨hal-00277248⟩
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