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Article Dans Une Revue Blood Année : 2022

How I manage pregnancy in women with Glanzmann thrombasthenia.

Résumé

Glanzmann thrombasthenia (GT) is a rare inherited platelet function disorder caused by a quantitative and/or qualitative defect of the αIIbβ3 integrin. Pregnancy and delivery is a recognized risk period for bleeding in women with GT. The newborn may also be affected by fetal and neonatal immune thrombocytopenia induced by the transplacental passage of maternal anti-αIIbβ3 antibodies, which can lead to severe hemorrhage and fetal loss. Pregnancy in GT women thus requires a multidisciplinary approach, including prepregnancy counseling, and a treatment plan for delivery for both the mother and child. In this article, we summarize the current knowledge on pregnancy in women with GT and describe how we manage this severe platelet disorder in our clinical practice.

Dates et versions

hal-03634120 , version 1 (07-04-2022)

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Mathieu Fiore, Loïc Sentilhes, Roseline d'Oiron. How I manage pregnancy in women with Glanzmann thrombasthenia.. Blood, 2022, ⟨10.1182/blood.2021011595⟩. ⟨hal-03634120⟩

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