Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis - Analyse de Xénobiotiques, Identification, Métabolisme Access content directly
Journal Articles Environmental Pollution Year : 2021

Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis

Sylvie Veyrenc
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  • PersonId : 985827
Christophe Regnault
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  • PersonId : 985826
Cécile Canlet
Marie Tremblay-Franco
Muriel Raveton
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  • PersonId : 860579
Stephane Reynaud

Abstract

Metabolic disorders induced by endocrine disruptors (ED) may contribute to amphibian population declines but no transgenerational studies have evaluated this hypothesis. Here we show that Xenopus tropicalis, exposed from the tadpole stage, to the ED benzo[a]pyrene (BaP, 50 ng.L−1) produced F2 progeny with delayed metamorphosis and sexual maturity. At the adult stage, F2–BaP females displayed fatty liver with inflammation, tissue disorganization and metabolomic and transcriptomic signatures typical of nonalcoholic steato-hepatitis (NASH). This phenotype, similar to that observed in F0 and F1 females, was accompanied by a pancreatic insulin secretory defect. Metabolic disrupted F2–BaP females laid eggs with metabolite contents significantly different from the control and these eggs did not produce viable progeny. This study demonstrated that an ED can induce transgenerational disruption of metabolism and population collapse in amphibians under laboratory conditions. These results show that ED benzo[a]pyrene can impact metabolism over multiple generations and support epidemiological studies implicating environmental EDs in metabolic diseases in humans.
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hal-03032378 , version 1 (02-01-2023)

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Attribution - NonCommercial

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Marie Usal, Sylvie Veyrenc, Marie Darracq--Ghitalla-Ciock, Christophe Regnault, Sophie Sroda, et al.. Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis. Environmental Pollution, 2021, ⟨10.1016/j.envpol.2020.116109⟩. ⟨hal-03032378⟩
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