Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma. - Centre Paul Strauss Accéder directement au contenu
Article Dans Une Revue British Journal of Cancer Année : 2006

Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.

Résumé

We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing.

Dates et versions

hal-00188070 , version 1 (15-11-2007)

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Citer

Danièle Muller, Régine Millon, Serge Théobald, Thomas Hussenet, Bohdan Wasylyk, et al.. Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.. British Journal of Cancer, 2006, 94 (7), pp.1041-4. ⟨10.1038/sj.bjc.6603036⟩. ⟨hal-00188070⟩
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