Low risk of mother-to-child transmission of hepatitis C virus in Yaounde, Cameroon: the ANRS 1262 study. - Centre Pasteur du Cameroun Accéder directement au contenu
Article Dans Une Revue American Journal of Tropical Medicine and Hygiene Année : 2005

Low risk of mother-to-child transmission of hepatitis C virus in Yaounde, Cameroon: the ANRS 1262 study.

Résumé

To assess mother-to-child transmission (MTCT) of hepatitis C virus (HCV) in Cameroon, 5,008 pregnant women were screened for HCV antibodies. Eighty-nine (1.8%) were HCV-antibody (HCV-Ab) positive. Among these, 7 (7.9%) were HBsAg positive, 6 (6.7%) HIV-positive, and one (1.1%) was co-infected by both hepatitis B virus (HBV) and HIV. Sixty-eight (76%) out of 89 HCV-Ab positive pregnant women were HCV-RNA positive. The HCV genotype determination indicated the predominance of genotype 4 (45.3%), followed by the genotypes 1 (28.1%) and 2 (26.6%). The mean HCV-RNA levels of 41 women at the time of delivery was 4.8 (range 0.06-34.7) x 10(6) RNA copies/mL. Finally, 35 women delivered 36 live children. None of those screened at 6 weeks and 6 months of age were HCV-RNA positive. The failure to detect HCV vertical transmission suggests that the mother-to-child transmission (MTCT) is not a major route of HCV transmission in Cameroon.

Domaines

Virologie

Dates et versions

hal-00542204 , version 1 (01-12-2010)

Identifiants

Citer

Richard Njouom, Christophe Pasquier, Ahidjo Ayouba, Mathurin Cyrille Tejiokem, Aurelia Vessiere, et al.. Low risk of mother-to-child transmission of hepatitis C virus in Yaounde, Cameroon: the ANRS 1262 study.. American Journal of Tropical Medicine and Hygiene, 2005, 73 (2), pp.460-466. ⟨10.4269/ajtmh.2005.73.460⟩. ⟨hal-00542204⟩

Collections

RIIP RIIP_CAMEROUN
45 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More