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Article Dans Une Revue Hepatology Année : 2021

Preliminary Evidence for Hepatitis Delta Virus Exposure in Patients Who Are Apparently Not Infected With Hepatitis B Virus

Résumé

Hepatitis delta virus (HDV) is a defective human virus that lacks the ability to produce its own envelope proteins and is thus dependent on the presence of a helper virus, which causes its surface proteins to produce infectious particles. Hepatitis B virus (HBV) was so far thought to be the only helper virus described to be associated to HDV. However, recent studies showed that divergent HDV-like viruses can be detected in fishes, birds, amphibians, and invertebrates without evidence of any HBV-like agent supporting infection (reviewed in Maya and Ploss(1)). Another recent study demonstrated that HDV can be transmitted and propagated in experimental infections ex vivo and in vivo by different enveloped viruses unrelated to HBV, including hepatitis C virus (HCV), flaviviruses like dengue and West Nile virus, and vesiculovirus.(2) Altogether, these results suggested that hepatitis D infection may, in theory, occur in patients carrying either virus.(2) These observations prompted us to search for HDV infection among patients who are HCV infected and in geographical regions with high HDV endemicity. The exact prevalence of HDV infection in Venezuela is unknown, but outbreaks of fulminant HDV infections have been reported in indigenous populations from the Amazon basin and Western Venezuela.(3) The high prevalence of HDV infection among these indigenous populations might have favored dissemination of HDV infection among other inhabitants in the country. Here, we investigated the possible HDV exposure in a cohort of Venezuelan patients infected with HCV.
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Dates et versions

hal-03244315 , version 1 (01-06-2021)

Identifiants

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Isabelle Chemin, Flor H Pujol, Caroline Scholtès, Carmen L Loureiro, Fouzia Amirache, et al.. Preliminary Evidence for Hepatitis Delta Virus Exposure in Patients Who Are Apparently Not Infected With Hepatitis B Virus. Hepatology, 2021, 73 (2), pp.861-864. ⟨10.1002/hep.31453⟩. ⟨hal-03244315⟩
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