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Structure: Internal structure identifier : 456201

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Xavier Fant , Emilie Durieu , Gaëtan Chicanne , Bernard Payrastre , Diego Sbrissa et al.
Molecular Pharmacology, 2014, 85 (3), pp.441-50. ⟨10.1124/mol.113.090837⟩
Journal articles inserm-01012086v1

Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors

Tania Tahtouh , Emilie Durieu , Benoit Villiers , Celine Bruyere , Thu Lan Nguyen et al.
Journal of Medicinal Chemistry, 2022, 65 (2), pp.1396-1417. ⟨10.1021/acs.jmedchem.1c01141⟩
Journal articles hal-03512536v1
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Nadège Loaëc , Eletta Attanasio , Benoît Villiers , Emilie Durieu , Tania Tahtouh et al.
Marine drugs, 2017, 15 (10), pp.316 -. ⟨10.3390/md15100316⟩
Journal articles hal-01640115v1

Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects

Solene Guiheneuf , Ludovic Paquin , Francois Carreaux , Emilie Durieu , Helene Benedetti et al.
Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩
Journal articles hal-01114583v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet et al.
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Journal articles hal-02141338v1
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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Benoit Souchet , Mickael Audrain , Jean Marie Billard , Julien Dairou , Romain Fol et al.
Acta Neuropathologica Communications, 2019, 7 (1), pp.46. ⟨10.1186/s40478-019-0678-6⟩
Journal articles hal-02324924v1
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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Thu Lan Nguyen , Arnaud Duchon , Antigoni Manousopoulou , Nadège Loaëc , Benoît Villiers et al.
Disease Models & Mechanisms, 2018, 11 (9), pp.dmm035634. ⟨10.1242/dmm.035634⟩
Journal articles hal-01862465v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

Amélie Bruel , Romain Bénéteau , Mylène Chabanne , Olivier Lozach , Rémy Le Guevel et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩
Journal articles hal-01086026v1
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Exploring the Synthesis of New 1-(4-Substitutedphenylamino) imidazo[1,5-a]indol-3-one Derivatives as Cyclized Analogs of Leucettines

Guillaume Burgy , Emmanuelle Limanton , François Carreaux , Emilie Durieu , Laurent Meijer et al.
Journal of Applied Pharmaceutical Science, 2014, 4 (6), pp.25 - 32. ⟨10.7324/JAPS.2014.40604⟩
Journal articles hal-01116022v1
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New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Solène Guihéneuf , Ludovic Paquin , François Carreaux , Emilie Durieu , Thierry Roisnel et al.
Molecular Diversity, 2014, 18 (2), pp.375-88. ⟨10.1007/s11030-014-9509-7⟩
Journal articles hal-01017003v1

Novel Tetrahydropyrido[1,2- a ]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

Rajâa Boulahjar , Aziz Ouach , Chiurato Matteo , Stéphane Bourg , Myriam Ravache et al.
Journal of Medicinal Chemistry, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
Journal articles hal-02904751v1
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Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A

Khadidja Bourahla , Solène Guihéneuf , Emmanuelle Limanton , Ludovic Paquin , Rémy Le Guével et al.
Pharmaceuticals, 2021, 14 (11), pp.1086-1117. ⟨10.3390/ph14111086⟩
Journal articles hal-03467664v1

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

Katy Billot , Charlène Coquil , Benoît Villiers , Béatrice Josselin-Foll , Nathalie Desban et al.
AJP Renal Physiology, 2018, ⟨10.1152/ajprenal.00489.2017⟩
Journal articles hal-01738526v1