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Structure: Internal structure identifier : 445287
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The adiponectin agonist, AdipoRon, inhibits steroidogenesis and cell proliferation in human luteinized granulosa cells

Jérémy Grandhaye , Sandy Hmadeh , Ingrid Plotton , Floriane Levasseur , Anthony Estienne et al.
Molecular and Cellular Endocrinology, 2021, 520, 14 p. ⟨10.1016/j.mce.2020.111080⟩
Journal articles hal-03122484v1

Two new cyclobutane dimers from Diospyros macrocarpa

C. Thieury , G. Herbette , V. Monnier , N. Lebouvier , E. Hnawia et al.
Natural Product Communications , 2017, 12 (8), pp.1277-1282. ⟨10.1177/1934578X1701200833⟩
Journal articles hal-01619687v1
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Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

Ahmad Sharanek , Audrey Burban , Matthew Burbank , Rémy Le Guevel , Ruoya Li et al.
Scientific Reports, 2016, 6 (1), pp.24709. ⟨10.1038/srep24709⟩
Journal articles hal-01326368v1

The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals

Hanane Akhdar , Said El Shamieh , Orlando Musso , Romain Désert , Wissam Joumaa et al.
PLoS ONE, 2016, 11 (12), pp.e0167543. ⟨10.1371/journal.pone.0167543⟩
Journal articles hal-01439220v1

Investigation on the synthesis of new 3-[4-(arylalkoxy)phenylethyl]-2-thioxo-1,3-thiazolidin-4-ones and their biological evaluation against cancer cells

Camille Déliko Dago , Christelle N'Ta Ambeu , Wacothon Karime Coulibaly , Yves-Alain Békro , Janat A. Mamyrbekova-Bekro et al.
Chemistry of Heterocyclic Compounds, 2017, 53 (3), pp.341--349. ⟨10.1007/s10593-017-2056-2⟩
Journal articles hal-01586061v1
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Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents

Stephane Sengmany , Mathilde Sitter , Eric Léonel , Erwan Le Gall , Gervaise Loirand et al.
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩
Journal articles hal-02053836v1

Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene-2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors

Camille Déliko Dago , Wacothon Karime Coulibaly , Yves-Alain Bekro , Janat A. Mamyrbekova-Bekro , Beatrice Foll-Josselin et al.
Medicinal Chemistry Research, 2016, 25 (12), pp.2940--2958. ⟨10.1007/s00044-016-1719-3⟩
Journal articles hal-01414293v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet et al.
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Journal articles hal-02141338v1
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Characterization of Glyceollins as Novel Aryl Hydrocarbon Receptor Ligands and Their Role in Cell Migration

Thu Ha Pham , Sylvain Lecomte , Remy Le Guevel , Aurélie Lardenois , Bertrand Evrard et al.
International Journal of Molecular Sciences, 2020, 21 (4), pp.1368. ⟨10.3390/ijms21041368⟩
Journal articles hal-02499347v1
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Synthesis and toxicity evaluation of hydrophobic Ionic Liquids for Volatile Organic Compounds biodegradation in a two-phase partitioning bioreactor

Alfredo Santiago Rodriguez Castillo , Solene Guiheneuf , Rémy Le Guével , Pierre-François Biard , Ludovic Paquin et al.
Journal of Hazardous Materials, 2016, 307, pp.221-230. ⟨10.1016/j.jhazmat.2015.12.043⟩
Journal articles hal-01254799v1

Microwave-assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities

A. Bouattour , M. Fakhfakh , S. Abid , L. Paquin , A. Corlu et al.
ARKIVOC - Online Journal of Organic Chemistry, 2017, 2017 (4), pp.291--302. ⟨10.24820/ark.5550190.p010.040⟩
Journal articles hal-01581215v1
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Reactivity Under Microwave Irradiation of 2-amino 4H-chromene-3-carbonitrile as tool for the construction of potential bioactive derivatives

Ali Bouattour , Mehdi Fakhfakh , Houcine Ammar , Ludovic Paquin , Jean-Pierre Bazureau et al.
3rd International Electronic Conference on Medicinal Chemistry, Nov 2022, Online, France
Conference papers hal-03872422v1
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A practical multi-step synthesis of ethyl N-functionalized β-amino benzimidazole acrylate derivatives as promising cytotoxic agents

Christelle N'Ta Ambeu , Rémy Le Guével , Anne Corlu , Janat Akhanovna Mamyrbekova , Jean-Pierre Bazureau et al.
Molecular Diversity, 2018, 22 (3), pp.685-708. ⟨10.1007/s11030-018-9824-5⟩
Journal articles hal-01808102v1
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Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases

Camille Déliko Dago , Christelle Ambeu , Wacothon-Karime Coulibaly , Yves-Alain Békro , Janat Mamyrbékova et al.
Molecules, 2015, 20 (7), pp.12412-12435. ⟨10.3390/molecules200712412⟩
Journal articles hal-01187427v1
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Goodness-of-t test for multistable Lévy processes

Ronan Le Guével
Communications in Statistics - Theory and Methods, In press, pp.1-31. ⟨10.1080/03610926.2019.1653922⟩
Journal articles hal-02275584v1
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Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure

Simon Bucher , Pégah Jalili , Dounia Le Guillou , Karima Begriche , Karine Rondel et al.
Environmental Toxicology, 2017, 32 (3), pp.1024-1036. ⟨10.1002/tox.22301⟩
Journal articles hal-01470709v1
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Discovery of Human-Similar Gene Fusions in Canine Cancers

Ronan Ulvé , Mélanie Rault , Mathieu Bahin , Laetitia Lagoutte , Jérôme Abadie et al.
Cancer Research, 2017, 77 (21), pp.5721-5727. ⟨10.1158/0008-5472.CAN-16-2691⟩
Journal articles hal-01647128v1
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Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases

Dabbugoddu Brahmaiah , Anagani Kanaka Durga Bhavani , Pasula Aparna , Nangunoori Sampath Kumar , Hélène Solhi et al.
Molecules, 2022, 27 (19), pp.6149. ⟨10.3390/molecules27196149⟩
Journal articles hal-03828358v1
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Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains

Appala Venkata Ramana Murthy , Vennu Narendar , Nangunoori Sampath Kumar , Pasula Aparna , Anagani Kanaka Durga Bhavani et al.
Bioorganic & Medicinal Chemistry Letters, 2021, 52, pp.128390. ⟨10.1016/j.bmcl.2021.128390⟩
Journal articles hal-03414697v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével et al.
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Journal articles hal-02055769v1
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Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-alpha

Houssein Al-Attrache , Ahmad Sharanek , Audrey Burban , Matthew Burbank , Thomas Gicquel et al.
Toxicology Letters, 2016, 258, pp.71--86. ⟨10.1016/j.toxlet.2016.06.008⟩
Journal articles hal-01372855v1
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In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Georg Tascher , Audrey Burban , Sandrine Camus , Marine Plumel , Stéphanie Chanon et al.
Cells, 2019, 8 (2), pp.E192. ⟨10.3390/cells8020192⟩
Journal articles hal-02050391v1

An Efficient Solvent-Free Microwave-Assisted Synthesis of Cinnamamides by Amidation Reaction Using Phenylboronic Acid/Lewis Base Co-catalytic System

Khadidja Khaldoun , Abdelmounaim Safer , Salima Saidi-Besbes , Bertrand Carboni , Remy Le Guevel et al.
Synthesis: Journal of Synthetic Organic Chemistry, 2019, 51 (20), pp.3891-3900. ⟨10.1055/s-0039-1690132⟩
Journal articles hal-02359980v1
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Synthesis and biological studies of new quinazolines with ether functions in position 2

D. Brahmaiah , A.K.D. Bhavani , P. Aparna , N.S. Kumar , H. Solhi et al.
ARKIVOC - Online Journal of Organic Chemistry, 2019, 2019 (5), pp.96-107. ⟨10.24820/ark.5550190.p010.859⟩
Journal articles hal-02161844v1
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Mechanisms of action and structure-activity relationships of cytotoxic flavokawain derivatives

Charlotte Thieury , Nicolas Lebouvier , Rémy Le Guével , Yann Barguil , Gaëtan Herbette et al.
Bioorganic and Medicinal Chemistry, 2017, 25 (6), pp.1817-1829. ⟨10.1016/j.bmc.2017.01.049⟩
Journal articles hal-01485126v1

Novel Tetrahydropyrido[1,2- a ]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

Rajâa Boulahjar , Aziz Ouach , Chiurato Matteo , Stéphane Bourg , Myriam Ravache et al.
Journal of Medicinal Chemistry, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
Journal articles hal-02904751v1

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

Aziz Ouach , Rajâa Boulahjar , Christine Vala , Stéphane Bourg , Pascal Bonnet et al.
European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
Journal articles hal-01295635v1
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At the crossroads of fertility and metabolism

Pascal Froment , Ingrid Plotton , Cecilia Giulivi , Stéphane Fabre , Rita Khoueiry et al.
Human Reproduction, 2022, 37 (6), pp.1207-1228. ⟨10.1093/humrep/deac067⟩
Journal articles hal-03658093v1
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De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas.

Sihem Mebarki , Romain Désert , Laurent Sulpice , Marie Sicard , Mireille Desille et al.
Oncotarget, 2016, 7 (26), pp.39026--39043. ⟨10.18632/oncotarget.9346⟩
Journal articles inserm-01335675v1
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Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A

Khadidja Bourahla , Solène Guihéneuf , Emmanuelle Limanton , Ludovic Paquin , Rémy Le Guével et al.
Pharmaceuticals, 2021, 14 (11), pp.1086-1117. ⟨10.3390/ph14111086⟩
Journal articles hal-03467664v1