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Structure: Internal structure identifier : 247222

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Xavier Fant , Emilie Durieu , Gaëtan Chicanne , Bernard Payrastre , Diego Sbrissa et al.
Molecular Pharmacology, 2014, 85 (3), pp.441-50. ⟨10.1124/mol.113.090837⟩
Journal articles inserm-01012086v1
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Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases

Camille Déliko Dago , Christelle Ambeu , Wacothon-Karime Coulibaly , Yves-Alain Békro , Janat Mamyrbékova et al.
Molecules, 2015, 20 (7), pp.12412-12435. ⟨10.3390/molecules200712412⟩
Journal articles hal-01187427v1

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis

F. Le Cann , C. Delehouzé , S. Leverrier-Penna , A. Filliol , A. Comte et al.
FEBS Journal, 2017, 284 (18), pp.3050-3068. ⟨10.1111/febs.14176⟩
Journal articles hal-01616420v1
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Nadège Loaëc , Eletta Attanasio , Benoît Villiers , Emilie Durieu , Tania Tahtouh et al.
Marine drugs, 2017, 15 (10), pp.316 -. ⟨10.3390/md15100316⟩
Journal articles hal-01640115v1
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From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Frédéric Lassagne , Timothy Langlais , Elsa Caytan , Emmanuelle Limanton , Ludovic Paquin et al.
Molecules, 2018, 23 (11), pp.2961. ⟨10.3390/molecules23112961⟩
Journal articles hal-03867783v1

Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene-2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors

Camille Déliko Dago , Wacothon Karime Coulibaly , Yves-Alain Bekro , Janat A. Mamyrbekova-Bekro , Beatrice Foll-Josselin et al.
Medicinal Chemistry Research, 2016, 25 (12), pp.2940--2958. ⟨10.1007/s00044-016-1719-3⟩
Journal articles hal-01414293v1

Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

Madani Hedidi , Julien Maillard , William Erb , Frédéric Lassagne , Yury Halauko et al.
Tetrahedron, 2016, 72 (39), pp.6467 - 6476. ⟨10.1016/j.tet.2016.08.056⟩
Journal articles hal-03875302v1
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Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

M. Hedidi , W. Erb , G. Bentabed-Ababsa , Floris Chevallier , L. Picot et al.
Tetrahedron, 2016, 72 (41), pp.6467--6476. ⟨10.1016/j.tet.2016.08.056⟩
Journal articles hal-01381138v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet et al.
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Journal articles hal-02141338v1
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6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

C. Delehouzé , S. Leverrier-Penna , F. Le Cann , A. Comte , M. Jacquard-Fevai et al.
Scientific Reports, 2017, 7 (1), pp.12931. ⟨10.1038/s41598-017-12788-4⟩
Journal articles hal-01616456v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével et al.
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Journal articles hal-02055769v1
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2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

Nahida Mokhtari Brikci-Nigassa , Ghenia Bentabed-Ababsa , William Erb , Floris Chevallier , Laurent Picot et al.
Tetrahedron, 2018, 74 (15), pp.1785-1801. ⟨10.1016/j.tet.2018.02.038⟩
Journal articles hal-01774406v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

Amélie Bruel , Romain Bénéteau , Mylène Chabanne , Olivier Lozach , Rémy Le Guevel et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩
Journal articles hal-01086026v1
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Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129

Marion Navarri , C. Jégou , Arnaud Bondon , Sandrine Pottier , Stéphane Bach et al.
Marine drugs, 2017, 15 (4), ⟨10.3390/md15040111⟩
Journal articles hal-01518044v1
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Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.

Wacothon Karime Coulibaly , Ludovic Paquin , Anoubilé Bénié , Yves-Alain Bekro , Emilie Durieux et al.
Scientia Pharmaceutica, 2012, 80 (4), pp.825-36. ⟨10.3797/scipharm.1206-04⟩
Journal articles inserm-00864810v1
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New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Solène Guihéneuf , Ludovic Paquin , François Carreaux , Emilie Durieu , Thierry Roisnel et al.
Molecular Diversity, 2014, 18 (2), pp.375-88. ⟨10.1007/s11030-014-9509-7⟩
Journal articles hal-01017003v1
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Fused Systems Based on 2-Aminopyrimidines: Synthesis Combining Deprotolithiation-in situ Zincation with N -Arylation Reactions and Biological Properties

Madani Hedidi , Julien Maillard , William Erb , Frédéric Lassagne , Yury S Halauko et al.
European Journal of Organic Chemistry, 2017, 2017 (39), pp.5903-5915. ⟨10.1002/ejoc.201701004⟩
Journal articles hal-01624382v1

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

Aziz Ouach , Rajâa Boulahjar , Christine Vala , Stéphane Bourg , Pascal Bonnet et al.
European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
Journal articles hal-01295635v1
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A combined experimental and theoretical study of the thermal [3+2] cycloaddition of carbonyl ylides with activated alkenes

Samira Hamza-Reguig , Ghenia Bentabed-Ababsa , Luis R Domingo , Mar Ríos-Gutiérrez , Stephanie Philippot et al.
Journal of Molecular Structure, 2018, 1157, pp.276-287. ⟨10.1016/j.molstruc.2017.12.052⟩
Journal articles hal-01695551v2

Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

Rajâa Boulahjar , Aziz Ouach , Chiurato Matteo , Stéphane Bourg , Myriam Ravache et al.
Journal of Medicinal Chemistry, 2012, 55, pp.9589-9606
Journal articles hal-00785213v1