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Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.

Lydie Sparfel , Maud Loewert , Laurence Huc , Léa Payen , André Guillouzo et al.
Toxicology Letters, 2002, 129 (3), pp.245-54
Journal articles hal-02673286v1

Identification of genes regulated by the environmental contaminant benzo(a)pyrene in primary human macrophages

Lydie Sparfel , Marie-Laure Pinel-Marie , Magali Boize , Serge Koscielny , Sophie Desmots et al.
Annual Meeting 100th American Association for Cancer Research, Apr 2009, Denver, United States
Conference papers hal-00673940v1

AhR-dependent induction of the NADPH oxidase component p47phox by benzo(a)pyrene in human macrophages

Marie-Laure Pinel-Marie , Lydie Sparfel , Sophie Desmots , Olivier Fardel
Annual Meeting 100th American Association for Cancer Research, Apr 2009, Denver, United States
Conference papers hal-00674272v1
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Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol a possible key role for xenobiotic metabolism and nitric oxide

Arnaud Tête , Isabelle Gallais , Muhammad Imran , Martine Chevanne , Marie Liamin et al.
Free Radical Biology and Medicine, 2018, 129, pp.323-337. ⟨10.1016/j.freeradbiomed.2018.09.042⟩
Journal articles hal-01888877v1
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Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

Marie Liamin , Hélène Le Mentec , Bertrand Evrard , Laurence Huc , Frédéric Chalmel et al.
International Journal of Molecular Sciences, 2018, 19 (11), pp.E3626. ⟨10.3390/ijms19113626⟩
Journal articles hal-01940253v1
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Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.

Lydie Sparfel , Laurence Huc , Marc Le Vée , Mireille Desille , Dominique Lagadic-Gossmann et al.
Biochemical Pharmacology, 2004, 67 (9), pp.1711-1719. ⟨10.1016/j.bcp.2004.01.005⟩
Journal articles hal-02681620v1
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Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models

Alexandre R.R. Pery , Céline Brochot , Sophie Desmots , Magali Boize , Lydie Sparfel et al.
Toxicology Letters, 2011, 201 (1), pp.8-14. ⟨10.1016/j.toxlet.2010.11.017⟩
Journal articles hal-00873317v1

Identification de nouvelles cibles moléculaires des hydrocarbures aromatiques polycycliques : implications potentielles pour l'analyse de risque

Olivier Fardel , David Gilot , Valérie Lecureur , E. Le Ferrec , Marc Le Vee et al.
Journées Scientifiques de l'AFSSET, Feb 2006, Maisons-Alfort, France
Conference papers hal-00699806v1
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Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone.

Claudie Morzadec , Mélinda Macoch , Lydie Sparfel , Saadia Kerdine-Römer , Olivier Fardel et al.
Free Radical Biology and Medicine, 2014, 71, pp.133-45. ⟨10.1016/j.freeradbiomed.2014.03.006⟩
Journal articles hal-01018643v1
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Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.

Laurence Huc , Lydie Sparfel , Mary Rissel , Marie-Thérèse Dimanche-Boitre , André Guillouzo et al.
FASEB Journal, 2004, 18 (2), pp.344-346. ⟨10.1096/fj.03-0316fje⟩
Journal articles hal-02678074v1

Identification d'une nouvelle cible moléculaire des hydrocarbures aromatiques dans les macrophages humains en culture primaire : le gène NCF1 codant pour la protéine p47phox et potentialisation de la production d'espèces réactives de l'oxygène en réponse au PMA

Marie-Laure Pinel-Marie , Lydie Sparfel , Olivier Fardel
Journée Ouest Génopole 'Stress Oxydant', Dec 2008, Rennes, France
Conference papers hal-00674279v1

Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene.

Lydie Sparfel , Marie-Laure Pinel-Marie , Magali Boize , Serge Koscielny , Sophie Desmots et al.
Toxicological Sciences, 2010, 114 (2), pp.247-59. ⟨10.1093/toxsci/kfq007⟩
Journal articles hal-00657921v1

The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation

Laurie Prigent , Marc Robineau , Stéphane Jouneau , Claudie Morzadec , Laetitia Louarn et al.
European Journal of Immunology, 2014, 44 (5), pp.1330--1340. ⟨10.1002/eji.201343920⟩
Journal articles hal-01063944v1

Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.

Normand Podechard , Valérie Lecureur , E. Le Ferrec , Isabelle Guenon , Lydie Sparfel et al.
Toxicology Letters, 2008, 177 (2), pp.130-7. ⟨10.1016/j.toxlet.2008.01.006⟩
Journal articles istex hal-00673238v1

Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin a

Lydie Sparfel
P53 strategies for fighting cancer, Nov 2008, Londres, United Kingdom
Conference papers hal-00673415v1

Exposition de macrophages humains aux hydrocarbures aromatiques polycycliques : identification de nouvelles cibles moléculaires

Lydie Sparfel , Marie-Laure Pinel-Marie , Magali Boize , Serge Koscielny , Alexandre R.R. Pery et al.
Journée Ouest Génopole 'Approche du stress par approche transcriptomique', Sep 2008, Brest, France
Conference papers hal-00674276v1
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Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes

Marie Liamin , Elisa Boutet-Robinet , Emilien L. Jamin , Morgane Fernier , Laure Khoury et al.
Biochemical Pharmacology, 2017, 137, pp.113-124. ⟨10.1016/j.bcp.2017.04.025⟩
Journal articles hal-01560145v1

Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes.

Claudie Morzadec , Mélinda Macoch , Marc Robineau , Lydie Sparfel , Olivier Fardel et al.
Toxicology and Applied Pharmacology, 2012, 262 (3), pp.217-22. ⟨10.1016/j.taap.2012.05.004⟩
Journal articles inserm-00872871v1

Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcalphaRI by the environmental contaminant benzo(a)pyrene in human macrophages

Lydie Sparfel , Marie-Laure Pinel-Marie , L. Louarn , Sophie Desmots , Olivier Fardel et al.
47. European Congress of Toxicology (EUROTOX 2011), Aug 2011, Paris, France
Conference papers ineris-00970856v1

Apports des approches " omiques " pour modéliser la cinétique et les effets de xénobiotiques chez l'homme

Alexandre R.R. Pery , Céline Brochot , M. Dumas , Magali Boize , Sophie Desmots et al.
Colloque ARET, Jun 2010, Paris, France
Conference papers hal-00674296v1

Intérêt potentiel de cibles géniques des hydrocarbures aromatiques polycycliques en tant que biomarqueurs d'exposition

Lydie Sparfel , Marie-Laure Pinel-Marie , Serge Koscielny , Sophie Desmots , Alexandre R.R. Pery et al.
Environnement, Risques & Santé, 2011, 10 (3), pp.195-199
Journal articles hal-00682429v1

Identification de nouveaux gènes cibles des hydrocarbures aromatiques polycycliques dans les macrophages humains en culture primaire par une approche transcriptomique

Lydie Sparfel , Marie-Laure Pinel-Marie , Magali Boize , Serge Koscielny , Sophie Desmots et al.
Congrès de la Société de Pharmaco-Toxicologie Cellulaire " Toxicologie prédictive : les voies du futur ", May 2010, Paris, France
Conference papers hal-00674292v1

Global effects of inorganic arsenic on gene expression profile in human macrophages.

Emilie Bourdonnay , Claudie Morzadec , Lydie Sparfel , Marie-Dominique Galibert , Stéphane Jouneau et al.
Molecular Immunology, 2009, 46 (4), pp.649-56. ⟨10.1016/j.molimm.2008.08.268⟩
Journal articles istex inserm-00355570v1

Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.

Lydie Sparfel , Julien van Grevenynghe , Marc Le Vee , Caroline Aninat , Olivier Fardel et al.
Carcinogenesis, 2006, 27 (3), pp.656-63. ⟨10.1093/carcin/bgi256⟩
Journal articles hal-00699629v1

Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst.

Marie-Laure Pinel-Marie , Lydie Sparfel , Sophie Desmots , Olivier Fardel
Free Radical Biology and Medicine, 2009, 47 (6), pp.825-34. ⟨10.1016/j.freeradbiomed.2009.06.025⟩
Journal articles istex hal-00673349v1
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Benzo(a) pyrene triggers desensitization of beta 2-adrenergic pathway

Abdullah Mayati , Normand Podechard , Manuelle Rineau , Lydie Sparfel , Dominique Lagadic-Gossmann et al.
Scientific Reports, 2017, 7 (1), pp.3262. ⟨10.1038/s41598-017-03646-4⟩
Journal articles hal-01560151v1

Inflammatory response to benzo(a)pyrene, a major environmental contaminant, in primary human macrophages

Normand Podechard , E. Le Ferrec , M. N'Diaye , Lydie Sparfel , David Gilot et al.
11ème Colloque Cytokines de la Société Française d'Immunologie, May 2009, Le Croisic, France
Conference papers hal-00674286v1
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MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement

Arnaud Tête , Isabelle Gallais , Muhammad Imran , Louis Legoff , Corinne Martin-Chouly et al.
Food and Chemical Toxicology, 2020, 146, pp.111798. ⟨10.1016/j.fct.2020.111798⟩
Journal articles hal-02978021v1