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A practical multi-step synthesis of ethyl N-functionalized β-amino benzimidazole acrylate derivatives as promising cytotoxic agents

Christelle N'Ta Ambeu , Rémy Le Guével , Anne Corlu , Janat Akhanovna Mamyrbekova , Jean-Pierre Bazureau et al.
Molecular Diversity, 2018, 22 (3), pp.685-708. ⟨10.1007/s11030-018-9824-5⟩
Journal articles hal-01808102v1
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Reactivity Under Microwave Irradiation of 2-amino 4H-chromene-3-carbonitrile as tool for the construction of potential bioactive derivatives

Ali Bouattour , Mehdi Fakhfakh , Houcine Ammar , Ludovic Paquin , Jean-Pierre Bazureau et al.
3rd International Electronic Conference on Medicinal Chemistry, Nov 2022, Online, France
Conference papers hal-03872422v1

Comparative localization and functional activity of the main hepatobiliary transporters in HepaRG cells and primary human hepatocytes.

Pamela Bachour-El Azzi , Ahmad Sharanek , Audrey Burban , Ruoya Li , Rémy Le Guével et al.
Toxicological Sciences, 2015, 145 (1), pp.157-168. ⟨10.1093/toxsci/kfv041⟩
Journal articles hal-01134682v1

Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene-2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors

Camille Déliko Dago , Wacothon Karime Coulibaly , Yves-Alain Bekro , Janat A. Mamyrbekova-Bekro , Beatrice Foll-Josselin et al.
Medicinal Chemistry Research, 2016, 25 (12), pp.2940--2958. ⟨10.1007/s00044-016-1719-3⟩
Journal articles hal-01414293v1
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Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents

Stephane Sengmany , Mathilde Sitter , Eric Léonel , Erwan Le Gall , Gervaise Loirand et al.
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩
Journal articles hal-02053836v1

Investigation on the synthesis of new 3-[4-(arylalkoxy)phenylethyl]-2-thioxo-1,3-thiazolidin-4-ones and their biological evaluation against cancer cells

Camille Déliko Dago , Christelle N'Ta Ambeu , Wacothon Karime Coulibaly , Yves-Alain Békro , Janat A. Mamyrbekova-Bekro et al.
Chemistry of Heterocyclic Compounds, 2017, 53 (3), pp.341--349. ⟨10.1007/s10593-017-2056-2⟩
Journal articles hal-01586061v1

Hypoxia differentially modulates the genomic stability of clinical-grade ADSCs and BM-MSCs in long-term culture

Nicolas Bigot , Audrey Mouche , Milena Preti , Séverine Loisel , Marie-Laure Renoud et al.
Stem Cells / Stem Cells (Miamisburg), 2015, 33 (12), pp.3608-3620. ⟨10.1002/stem.2195⟩
Journal articles hal-01214007v1

Monoclonal antibodies against human translation termination factor eRF3 and their utilization for sub-cellular localization of eRF3.

Marie-Madeleine Delage , Stéphanie Dutertre , Rémy Le Guével , Ludmila Frolova , Nadia Berkova et al.
J BIOCHEM, 2011, 150 (1), pp.49-59. ⟨10.1093/jb/mvr035⟩
Journal articles inserm-00582996v1

Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.

Hélène Dubois-Pot-Schneider , Karim Fekir , Cédric Coulouarn , Denise Glaise , Caroline Aninat et al.
Hepatology, 2014, 60 (6), pp.2077-90. ⟨10.1002/hep.27353⟩
Journal articles hal-01134747v1

Staphylococcus aureus-induced cytopathic effect on the mammalian cells

Ludmila Alekseeva , Rémy Le Guével , Lucie Rault , Caroline Le Marechal , Claire Piquet-Pellorce et al.
4 Congress of European Microbiologists FEMS 2011, Jun 2011, Genève, Switzerland. , 2011
Conference poster hal-02808973v1

Direct cooperation between estrogen receptors and astrocyte-specific factors elicits high activity of the zebrafish brain aromatase gene

Arnaud Menuet , Elisabeth Pellegrini , Isabelle Anglade , Rémy Le Guével , Olivier Kah et al.
2nd International Meeting Steroids and nervous system, February 22-26, Torino, Italy, 2003, Torino, Italy
Conference papers hal-00107019v1

Microwave-assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities

A. Bouattour , M. Fakhfakh , S. Abid , L. Paquin , A. Corlu et al.
ARKIVOC - Online Journal of Organic Chemistry, 2017, 2017 (4), pp.291--302. ⟨10.24820/ark.5550190.p010.040⟩
Journal articles hal-01581215v1
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Synthesis and toxicity evaluation of hydrophobic Ionic Liquids for Volatile Organic Compounds biodegradation in a two-phase partitioning bioreactor

Alfredo Santiago Rodriguez Castillo , Solene Guiheneuf , Rémy Le Guével , Pierre-François Biard , Ludovic Paquin et al.
Journal of Hazardous Materials, 2016, 307, pp.221-230. ⟨10.1016/j.jhazmat.2015.12.043⟩
Journal articles hal-01254799v1

Two new cyclobutane dimers from Diospyros macrocarpa

C. Thieury , G. Herbette , V. Monnier , N. Lebouvier , E. Hnawia et al.
Natural Product Communications , 2017, 12 (8), pp.1277-1282. ⟨10.1177/1934578X1701200833⟩
Journal articles hal-01619687v1

Expression and regulation of brain aromatase in teleost fish.

Olivier Kah , Arnaud Menuet , Elisabeth Pellegrini , Rémy Le Guével , Marie-Madeleine Guéguen et al.
Symposium on Fish Growth and Reproduction, October 26-29, Keelung, Taiwan, 2003, Keelung, Taiwan
Conference papers hal-00106939v1
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Structure-based design of human immuno- and constitutive proteasomes inhibitors

N. Richy , D. Sarraf , X. Maréchal , N. Janmamode , E. Genin et al.
European Journal of Medicinal Chemistry, 2018, 145, pp.570-587. ⟨10.1016/j.ejmech.2018.01.013⟩
Journal articles hal-01713510v1
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Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases

Dabbugoddu Brahmaiah , Anagani Kanaka Durga Bhavani , Pasula Aparna , Nangunoori Sampath Kumar , Hélène Solhi et al.
Molecules, 2022, 27 (19), pp.6149. ⟨10.3390/molecules27196149⟩
Journal articles hal-03828358v1

Prospective study directed to the synthesis of unsymmetrical linked bis-5-arylidene rhodanine derivatives via “one-pot two steps” reactions under microwave irradiation with their antitumor activity

Wacothon Karime Coulibaly , Ludovic Paquin , Anoubilé Bénie , Yves-Alain Békro , Rémy Le Guével et al.
Medicinal Chemistry Research, 2015, 24 (4), pp.1653-1661. ⟨10.1007/s00044-014-1186-7⟩
Journal articles hal-01114518v1

Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic Acid are affected by the presence of short alkyl groups on the phenyl ring.

Frédérik Oger , Aurélien Lecorgne , Elisa Sala , Vanessa Nardese , Florence Demay et al.
Journal of Medicinal Chemistry, 2010, 53 (5), pp.1937-50. ⟨10.1021/jm901561u⟩
Journal articles hal-00462114v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével et al.
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Journal articles hal-02055769v1

Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.

Rémy Le Guével , Frédérik Oger , Aurélien Lecorgne , Zuzana Dudasova , Soizic Chevance et al.
Bioorganic and Medicinal Chemistry, 2009, 17 (19), pp.7021-30. ⟨10.1016/j.bmc.2009.07.079⟩
Journal articles istex hal-00422061v1

Toxicologie predictive: les voies du futur

Ph Detilleux , L Vallier , C Legallais , E Leclerc , M Prot J et al.
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Conference papers hal-01122677v1
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The novel antibacterial compound walrycin A induces human PXR transcriptional activity.

Alexandre Berthier , Frédérik Oger , Céline Gheeraert , Abdel Boulahtouf , Rémy Le Guével et al.
Toxicological Sciences, 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
Journal articles inserm-00672104v1
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Synthesis and biological studies of new quinazolines with ether functions in position 2

D. Brahmaiah , A.K.D. Bhavani , P. Aparna , N.S. Kumar , H. Solhi et al.
ARKIVOC - Online Journal of Organic Chemistry, 2019, 2019 (5), pp.96-107. ⟨10.24820/ark.5550190.p010.859⟩
Journal articles hal-02161844v1

Electrochemical synthesis and characterisation of alternating tripyridyl-dipyrrole molecular strands with multiple nitrogen-based donor-acceptor binding sites.

Alexandra Tabatchnik-Rebillon , Christophe Aubé , Hicham Bakkali , Thierry Delaunay , Gabriel Thia Manh et al.
Chemistry - A European Journal, 2010, 16 (39), pp.11876-89. ⟨10.1002/chem.201000859⟩
Journal articles istex hal-00742561v1
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Mechanisms of action and structure-activity relationships of cytotoxic flavokawain derivatives

Charlotte Thieury , Nicolas Lebouvier , Rémy Le Guével , Yann Barguil , Gaëtan Herbette et al.
Bioorganic and Medicinal Chemistry, 2017, 25 (6), pp.1817-1829. ⟨10.1016/j.bmc.2017.01.049⟩
Journal articles hal-01485126v1

Inactivation of the Nuclear Orphan Receptor COUP-TFII by Small Chemicals

Rémy Le Guével , Frederik Oger , Celia P. Martinez-Jimenez , Maud Bizot , Celine Gheeraert et al.
ACS Chemical Biology, 2017, 12 (3), pp.654-663. ⟨10.1021/acschembio.6b00593⟩
Journal articles hal-01497231v1

Inactivation of AMPK in human granulosa cells

Pascal Froment , Charlène Rouillon , Joëlle Dupont , I Plotton , Rémy Le Guével et al.
50. Annual meeting of the Society for the Study of Reproduction SSR, 2017, washington, United States. , 2017
Conference poster hal-02787865v1
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Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.

Wacothon Karime Coulibaly , Ludovic Paquin , Anoubilé Bénié , Yves-Alain Bekro , Emilie Durieux et al.
Scientia Pharmaceutica, 2012, 80 (4), pp.825-36. ⟨10.3797/scipharm.1206-04⟩
Journal articles inserm-00864810v1

Distribution of aromatase mRNA and protein in the brain and pituitary of female rainbow trout: Comparison with estrogen receptor alpha.

Arnaud Menuet , Isabelle Anglade , Rémy Le Guével , Elisabeth Pellegrini , Farzad Pakdel et al.
Journal of Comparative Neurology, 2003, 462 (2), pp.180-93. ⟨10.1002/cne.10726⟩
Journal articles istex hal-00295588v1