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authFullName_s : Pierre van de Weghe

Synthesis of peptidomimetics and chemo-biological tools for CD95/PLC gamma 1 interaction analysis

Ha Thanh Nguyen , Jean-Philippe Guégan , Amanda Poissonnier , Florence Jouan , Daniel Best et al.
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
Journal articles hal-02278513v1

Transition metal C-H activation: application to stereoselective synthesis of natural products and drugs

Mickael Jean , Pierre van de Weghe
Stereoselective Synthesis of Drugs and Natural Products, Wiley, pp.667-686, 2013, 978-1-118-03217-6
Book sections hal-00868413v1

Probing the side chain tolerance for inhibitors of the CD95/PLCγ1 interaction

Ha Thanh Nguyen , Jean-Philippe Guegan , Daniel Best , Pierre van de Weghe , Nicolas Levoin et al.
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩
Journal articles hal-02393634v1

Gold-catalyzed C-S Bond Formation from Thiols

Mickael Jean , Jacques Renault , Pierre van de Weghe , Naoki Asao
Tetrahedron Letters, 2010, 51 (2), pp.378-381. ⟨10.1016/j.tetlet.2009.11.025⟩
Journal articles istex hal-00844444v1
Image document

Enantioselective Prins cyclization: BINOL-derived phosphoric acid and CuCl synergistic catalysis.

Claudia Lalli , Pierre van de Weghe
Chemical Communications, 2014, 50 (56), pp.7495-8. ⟨10.1039/C4CC02826K⟩
Journal articles hal-01116325v1

Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

Amélie Fouqué , Olivier Delalande , Mickael Jean , Rémy Castellano , Emmanuelle Josselin et al.
Journal of Medicinal Chemistry, 2019, 62 (20), pp.9339-9340. ⟨10.1021/acs.jmedchem.9b01578⟩
Journal articles hal-02526957v1

Disrupting the CD95-PLC gamma 1 interaction prevents Th17-driven inflammation

Amanda Poissonnier , Jean-Philippe Guegan , Ha Thanh Nguyen , Daniel Best , Nicolas Levoin et al.
Nature Chemical Biology, 2018, 14 (12), pp.1079-+. ⟨10.1038/s41589-018-0162-9⟩
Journal articles hal-01976911v1

Synthesis of Stachybotrin C

Pierre van de Weghe
Lebanese University Beirut, February 21th, 2013, Feb 2013, Beyrouth, Lebanon
Conference papers hal-00872739v1
Image document

Lichen butyrolactone derivatives disrupt oral bacterial membrane

Alaa Sweidan , Imen Smida , Marylene Chollet-Krugler , Aurélie Sauvager , Julien Vallet et al.
Fitoterapia, 2019, 137, pp.104274. ⟨10.1016/j.fitote.2019.104274⟩
Journal articles hal-02280840v1

Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis

Gabriella da Rosa Monte Machado , Denise Diedrich , Thaís Carine Ruaro , Aline Rigon Zimmer , Mário Lettieri Teixeira et al.
Brazilian Journal of Microbiology, 2020, 51 (4), pp.1691-1701. ⟨10.1007/s42770-020-00348-4⟩
Journal articles hal-04022492v1

New pi3k​/akt​/mtor inhibitors and pharmaceutical uses thereof

Mickael Jean , Amelie Fouque , Patrick Legembre , Pierre van de Weghe
France, Patent n° : WO 2015044229 / EP 2853530. 2015
Patents hal-01139914v1

Intramolecular Imino Diels−Alder Reaction: Progress toward the Synthesis of Uncialamycin

Sandy Desrat , Pierre van de Weghe
Journal of Organic Chemistry, 2009, 74 (17), pp.6728-6734. ⟨10.1021/jo901291t⟩
Journal articles hal-02355118v1

Setbacks and Hopes: En Route to the Synthesis of Uncialamycin

Sandy Desrat , Mickaël Jean , Pierre van de Weghe
Tetrahedron, 2011, 67 (39), pp.7510-7516. ⟨10.1016/j.tet.2011.07.090⟩
Journal articles istex hal-00843821v1
Image document

Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics

Cédric Tresse , Richard Radigue , Rafael Gomes von Borowski , Marion Thepaut , Hong Hanh Le et al.
Bioorganic and Medicinal Chemistry, 2019, 27 (21), pp.115097. ⟨10.1016/j.bmc.2019.115097⟩
Journal articles hal-02304766v1

Synthesis of stachybotrin C and all of its stereoisomers: structure revision.

Maiwenn Jacolot , Mickael Jean , Naresh Tumma , Arnaud Bondon , Srivari Chandrasekhar et al.
Journal of Organic Chemistry, 2013, 78 (14), pp.7169-75. ⟨10.1021/jo401116r⟩
Journal articles hal-00862776v1

Synthetic studies towards Stachybotrin C

Naresh Tumma , Maiwenn Jacolot , Mickael Jean , Srivari Chandrasekhar , Pierre van de Weghe et al.
SYNLETT, 2012, 23 (20), pp.2919-2922. ⟨10.1055/s-0032-1317528⟩
Journal articles hal-00841803v1
Image document

Synergistic Effect of the TiCl4/p-TsOH Promoter System on the Aza-Prins Cyclization

Vianney Durel , Claudia Lalli , Thierry Roisnel , Pierre van de Weghe
Journal of Organic Chemistry, 2016, 81 (3), pp.849-859. ⟨10.1021/acs.joc.5b02342⟩
Journal articles hal-01256843v1

Gold-catalyzed intramolecular hydroarylation of olefins. Scope evaluation and preliminary mechanistic studies

Mickael Jean , Pierre van de Weghe
Tetrahedron Letters, 2011, 52 (27), pp.3509-3513. ⟨10.1016/j.tetlet.2011.04.122⟩
Journal articles istex hal-00843552v1

Strategy of total synthesis based on the use of Rh-catalyzed stereoselective 1,4-addition

M. Jean , B. Casanova , S. Gnoatto , Pierre van de Weghe
Organic & Biomolecular Chemistry, 2015, 13 (35), pp.9168--9175. ⟨10.1039/c5ob01402f⟩
Journal articles hal-01188229v1

A DFT-D evaluation of the complexation of a molecular tweezer with small aromatic molecules

Jérôme Graton , Jean-Yves Le Questel , Béatrice Legouin , Philippe Uriac , Pierre van de Weghe et al.
Chemical Physics Letters, 2012, 522, pp.11-16. ⟨10.1016/J.CPLETT.2011.11.076⟩
Journal articles istex hal-00841527v1

Unprecedented synergistic effects between weak Lewis and Brønsted acids in Prins cyclization.

Prashant Borkar , Pierre van de Weghe , Basi V. Subba Reddy , Jhillu Singh Yadav , René Grée et al.
Chemical Communications, 2012, 48 (74), pp.9316-8. ⟨10.1039/c2cc35052a⟩
Journal articles hal-00841700v1

When the nine-membered enediynes play hide and seek.

Mickaël Jean , Sophie Tomasi , Pierre van de Weghe
Organic & Biomolecular Chemistry, 2012, 10 (37), pp.7453-6. ⟨10.1039/c2ob26033f⟩
Journal articles hal-00841706v1
Image document

Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity

Chinh Pham The , Tuyet Anh Dang Thi , Thi Phuong Hoang , Quoc Anh Ngo , Duy Tien Doan et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (22), pp.5216-5218. ⟨10.1016/j.bmcl.2014.09.065⟩
Journal articles hal-01080910v1

A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

Amelie Fouque , Olivier Delalande , Mickael Jean , Remy Castellano , Emmanuelle Josselin et al.
Journal of Medicinal Chemistry, 2015, 58 (16), pp.6559-6573. ⟨10.1021/acs.jmedchem.5b00991⟩
Journal articles hal-01187307v1

PNSCM : short overview of research topics.

Pierre van de Weghe
Faculté de pharmacie, Universidade Federal Rio Grande dol Sul, Porto Alegre, Brésil, 10 mai 2013, May 2013, Porto Alegre, Brazil
Conference papers hal-00872741v1

Molecular Tweezers in Host-Guest Complexes: A Computational Study through a DFT-D Approach

Jérôme Graton , Béatrice Legouin , François Besseau , Philippe Uriac , Jean-Yves Le Questel et al.
Journal of Physical Chemistry C, 2012, 116 (43), pp.23067-23074. ⟨10.1021/jp307188q⟩
Journal articles hal-00841791v1

Antibacterial activities of natural lichen compounds against Streptococcus gordonii and Porphyromonas gingivalis

Alaa Sweidan , Marylene Chollet-Krugler , Aurélie Sauvager , Pierre van de Weghe , Ali Chokr et al.
Fitoterapia, 2017, 121, pp.164-169. ⟨10.1016/j.fitote.2017.07.011⟩
Journal articles hal-01579650v1

A novel aryl-hydrazide from the marine lichen Lichina pygmaea: isolation, synthesis of derivatives, and cytotoxicity assays.

Catherine Roullier , Marylene Chollet-Krugler , Pierre van de Weghe , Françoise Lohézic-Le Dévéhat , Joël Boustie et al.
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (15), pp.4582-6. ⟨10.1016/j.bmcl.2010.06.013⟩
Journal articles istex hal-00844454v1

Molecular tweezers: Synthesis and formation of host-guest complexes

Béatrice Legouin , Maud Gayral , Philippe Uriac , Jean-François Cupif , Nicolas Levoin et al.
European Journal of Organic Chemistry, 2010, 2010 (28), pp.5503-5508. ⟨10.1002/ejoc.201000729⟩
Journal articles istex hal-00844479v1

Novel chiral molecular tweezer from (+)-usnic acid.

Béatrice Legouin , Philippe Uriac , Sophie Tomasi , Loic Toupet , Arnaud Bondon et al.
Organic Letters, 2009, 11 (3), pp.745-748. ⟨10.1021/ol802842m⟩
Journal articles inserm-00713269v1