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authFullName_s : Pascal Loyer

Highly efficient SiRNA and gene transfer into hepatocyte-like HepaRG cells and primary human hepatocytes: new means for drug metabolism and toxicity studies.

Véronique Laurent , Denise Glaise , Tobias Nübel , David Gilot , Anne Corlu et al.
Methods in Molecular Biology, 2013, 987, pp.295-314. ⟨10.1007/978-1-62703-321-3_25⟩
Journal articles hal-00865763v1

Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.

Julie Dumont , Rozenn Jossé , Carine Lambert , Sébastien Anthérieu , Véronique Laurent et al.
Toxicology and Applied Pharmacology, 2010, 249 (1), pp.91-100. ⟨10.1016/j.taap.2010.08.027⟩
Journal articles istex hal-00742145v1
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Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells

Laure Peyta , Kathleen Jarnouen , Michelle Pinault , Cyrille Guimaraes , Jean-Paul Pais de Barros et al.
Biochimica biophysica acta (BBA) - Bioenergetics, 2016, 1857 (4), pp.443-453. ⟨10.1016/j.bbabio.2016.01.002⟩
Journal articles hal-01259219v1
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Highly efficient gene transfer into hepatocyte-like HepaRG cells: new means for drug metabolism and toxicity studies

Véronique Laurent , Aurore Fraix , Tristan Montier , Sandrine Cammas-Marion , Catherine Ribault et al.
Biotechnology Journal, 2010, 5 (3), pp.314. ⟨10.1002/biot.200900255⟩
Journal articles hal-00552337v1
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Natural and synthetic poly(malic acid)-based derivates: A family of versatile biopolymers for the design of drug nanocarriers.

Pascal Loyer , Sandrine Cammas-Marion
Journal of Drug Targeting, 2014, 22 (7), pp.556. ⟨10.3109/1061186X.2014.936871⟩
Journal articles hal-01063205v1
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Ethanol upregulates the P2X7 purinergic receptor in human macrophages

Brendan Le Dare , Tatiana Victoni , Aude Bodin , Manuel Vlach , Elise Vene et al.
Fundamental & Clinical Pharmacology, 2019, 33 (1), pp.63-74. ⟨10.1111/fcp.12433⟩
Journal articles hal-01937258v1
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Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG cell-based biosensors to monitor hepatocyte differentiation, drug metabolism and toxicity

Manuel Vlach , Nicolas Quesnot , Hélène Dubois-Pot-Schneider , Catherine Ribault , Yann Verres et al.
Sensors, 2019, 19 (10), pp.2245. ⟨10.3390/s19102245⟩
Journal articles hal-02152870v1
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Regulation of the hepatocyte cell cycle: signaling pathways and protein kinases.

Pascal Loyer , Anne Corlu , Chantal Desdouets
International Journal of Hepatology, 2012, 2012, pp.592354. ⟨10.1155/2012/592354⟩
Journal articles inserm-00864155v1

Reperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway.

Hélène Duval , Sasse-Fanie Mbatchi , Stéphane Grandadam , Claire Legendre , Pascal Loyer et al.
Journal of Hepatology, 2010, 52 (4), pp.560-9. ⟨10.1016/j.jhep.2010.01.013⟩
Journal articles istex hal-00742147v1

Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25

Riheb Jabeur , Caroline Corbel , Pascal Loyer , Annabelle Le Parc , Adelaide Le Grand et al.
Biochemistry, 2023, 62 (9), pp.1452-1463. ⟨10.1021/acs.biochem.2c00691⟩
Journal articles hal-04089029v1
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Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes

Nicolas Quesnot , Simon Bucher , Christina Gade , Manuel Vlach , Elise Vene et al.
Archives of Toxicology, 2018, 92 (10), pp.3077-3091. ⟨10.1007/s00204-018-2300-2⟩
Journal articles hal-01863847v1

IL-1β production is dependent of the activation of purinergic receptors and NLRP3 pathway in human macrophages

Thomas Gicquel , Sacha Robert , Pascal Loyer , Tatiana Victoni , Aude Bodin et al.
FASEB Journal, 2015, 29 (10), pp.4162-4173. ⟨10.1096/fj.14-267393⟩
Journal articles hal-01169797v1
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Circumsporozoite Protein of Plasmodium berghei- and George Baker Virus A-Derived Peptides Trigger Efficient Cell Internalization of Bioconjugates and Functionalized Poly(ethylene glycol)-b-poly(benzyl malate)-Based Nanoparticles in Human Hepatoma Cells

Elise Vene , Kathleen Jarnouen , Catherine Ribault , Manuel Vlach , Yann Verres et al.
Pharmaceutics, 2022, 14 (4), pp.804. ⟨10.3390/pharmaceutics14040804⟩
Journal articles hal-03657832v1
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Degradable and biocompatible nanoparticles decorated with cyclic RGD peptide for efficient drug delivery to hepatoma cells in vitro.

Pascal Loyer , Wahib Bedhouche , Zhi Wei Huang , Sandrine Cammas-Marion
International Journal of Pharmaceutics, 2013, 454 (2), pp.727-37. ⟨10.1016/j.ijpharm.2013.05.060⟩
Journal articles hal-00861299v1

Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration

Nawal Belmadi , Patrick Midoux , Pascal Loyer , Catherine Passirani , Chantal Pichon et al.
Biotechnology Journal, 2015, 10 (9), pp.1370-1389. ⟨10.1002/biot.201400841⟩
Journal articles istex hal-01162373v1
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Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke

Camila Oliveira da Silva , Thomas Gicquel , Yoann Daniel , Thiago Bartholo , Elise Vene et al.
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-68753-1⟩
Journal articles hal-02929043v1
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Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy

Romain Eychenne , Christelle Bouvry , Mickael Bourgeois , Pascal Loyer , Eric Benoist et al.
Molecules, 2020, 25 (17), pp.4012. ⟨10.3390/molecules25174012⟩
Journal articles hal-02957763v1

Culture Conditions Promoting Hepatocyte Proliferation and Cell Cycle Synchronization

Anne Corlu , Pascal Loyer
Methods in Molecular Biology, 2015, 1250, pp.27--51. ⟨10.1007/978-1-4939-2074-7_3⟩
Journal articles hal-01187298v1
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Araf51 with improved transglycosylation activities: One engineered biocatalyst for one specific acceptor

Alizé Pennec , Richard Daniellou , Pascal Loyer , Caroline Nugier-Chauvin , Vincent Ferrières et al.
Carbohydrate Research, 2015, 402, pp.50-55. ⟨10.1016/j.carres.2014.10.031⟩
Journal articles hal-01086640v1

New functional degradable and bio-compatible nanoparticles based on poly(malic acid) derivatives for site-specific anti-cancer drug delivery.

Zhi Wei Huang , Véronique Laurent , Ghizlane Chetouani , Julia Y. Ljubimova , Eggehard Holler et al.
International Journal of Pharmaceutics, 2012, 423 (1), pp.84-92. ⟨10.1016/j.ijpharm.2011.04.035⟩
Journal articles inserm-00864846v1

Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells

Nicolas Quesnot , Karine Rondel , Marc Audebert , Sophie Martinais , Denise Glaise et al.
Mutagenesis, 2016, 31 (1), pp.43-50. ⟨10.1093/mutage/gev059⟩
Journal articles hal-01187325v1
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Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Pascal Loyer , Janeen H Trembley
Seminars in Cell and Developmental Biology, 2020, 107, pp.36-45. ⟨10.1016/j.semcdb.2020.04.016⟩
Journal articles hal-02864472v1
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Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia

Laure Peyta , Kathleen Jarnouen , Michelle Pinault , Cédric Coulouarn , Cyrille Guimaraes et al.
BBA - Biochimica et Biophysica Acta, 2015, 1851 (11), pp.1490-1500. ⟨10.1016/j.bbalip.2015.08.008⟩
Journal articles hal-01197346v1
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Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices.

Francis Finot , Régis Masson , Fabienne Desmots , Catherine Ribault , Nicole Bichet et al.
International Journal of Hepatology, 2012, 2012, pp.785786. ⟨10.1155/2012/785786⟩
Journal articles inserm-00864148v1
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Synthesis of Poly(Dimethylmalic Acid) Homo- and Copolymers to Produce Biodegradable Nanoparticles for Drug Delivery Cell Uptake and Biocompatibility Evaluation in Human Heparg Hepatoma Cells

Ali Khalil , Saad Saba , Catherine Le Ribault , Manuel Vlach , Pascal Loyer et al.
Polymers, 2020, 12 (8), pp.1705. ⟨10.3390/polym12081705⟩
Journal articles hal-02930234v1
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Dosimetric parameters predicting contralateral liver hypertrophy after unilobar radioembolization of hepatocellular carcinoma

Xavier Palard , Julien Edeline , Yan Rolland , Samuel Le Sourd , Marc Pracht et al.
European Journal of Nuclear Medicine and Molecular Imaging, 2018, 45 (3), pp.392-401. ⟨10.1007/s00259-017-3845-7⟩
Journal articles hal-01709935v1
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Liposome-Mediated Gene Transfer in Differentiated HepaRG™ Cells: Expression of Liver Specific Functions and Application to the Cytochrome P450 2D6 Expression

Manuel Vlach , Hugo Coppens-Exandier , Agnès Jamin , Mathieu Berchel , Julien Scaviner et al.
Cells, 2022, 11 (23), pp.3904. ⟨10.3390/cells11233904⟩
Journal articles hal-03930086v1
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Poly(malic acid) bearing Doxorubicin and N-Acetyl Galactosamine as a site-specific prodrug for targeting hepatocellular carcinoma

Nivishna Venkatraj , M. J. Nanjan , Pascal Loyer , M. J. N. Chandrasekar , Sandrine Cammas-Marion et al.
Journal of Biomaterials Science, Polymer Edition, 2017, 28 (10-12), pp.1140-1157. ⟨10.1080/09205063.2017.1311294⟩
Journal articles hal-01579649v1

Elaboration of nanocarriers based on biocompatible polymers for the specific vectorisation of an imaging agent

Oceane Malval , Elise Vene , Pascal Loyer , Sandrine Cammas-Marion , Nicolas Lepareur et al.
Journal of Labelled Compounds and Radiopharmaceuticals, 2019, 62, pp.S356-S357
Journal articles hal-02177795v1
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Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition

Amélie Foucault , Noemie Ravalet , Joevin Besombes , Frédéric Picou , Nathalie Gallay et al.
Cancers, 2021, 13 (22), pp.5699. ⟨10.3390/cancers13225699⟩
Journal articles hal-03468294v1