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authFullName_s : Marie-Anne Robin

Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.

Julie Dumont , Rozenn Jossé , Carine Lambert , Sébastien Anthérieu , Véronique Laurent et al.
Toxicology and Applied Pharmacology, 2010, 249 (1), pp.91-100. ⟨10.1016/j.taap.2010.08.027⟩
Journal articles istex hal-00742145v1

Central role of mitochondria in drug-induced liver injury.

Dominique Pessayre , Bernard Fromenty , Alain Berson , Marie-Anne Robin , Philippe Lettéron et al.
Drug Metabolism Reviews, 2012, 44 (1), pp.34-87. ⟨10.3109/03602532.2011.604086⟩
Journal articles hal-00866123v1

Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Jacinthe Aubert , Karima Begriche , Matthieu Delannoy , Isabelle Morel , Julie Pajaud et al.
Journal of Pharmacology and Experimental Therapeutics, 2012, 342 (3), pp.676-87. ⟨10.1124/jpet.112.193813⟩
Journal articles inserm-00864718v1

Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.

Julie Massart , Marie-Anne Robin , Fanny Noury , Alain Fautrel , P. Lettéron et al.
British Journal of Pharmacology, 2012, 165 (5), pp.1361-74. ⟨10.1111/j.1476-5381.2011.01580.x⟩
Journal articles hal-00740120v1

Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.

Rozenn Josse , Julie Dumont , Alain Fautrel , Marie-Anne Robin , André Guillouzo et al.
Toxicology and Applied Pharmacology, 2012, 258 (2), pp.176-87. ⟨10.1016/j.taap.2011.10.019⟩
Journal articles istex hal-00866033v1
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Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG cell-based biosensors to monitor hepatocyte differentiation, drug metabolism and toxicity

Manuel Vlach , Nicolas Quesnot , Hélène Dubois-Pot-Schneider , Catherine Ribault , Yann Verres et al.
Sensors, 2019, 19 (10), pp.2245. ⟨10.3390/s19102245⟩
Journal articles hal-02152870v1

Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease

Anaïs Michaut , Caroline Moreau , Marie-Anne Robin , Bernard Fromenty
Liver International, 2014, 34 (7), pp.e171-9. ⟨10.1111/liv.12514⟩
Journal articles hal-01128195v1
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Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes

Nicolas Quesnot , Simon Bucher , Christina Gade , Manuel Vlach , Elise Vene et al.
Archives of Toxicology, 2018, 92 (10), pp.3077-3091. ⟨10.1007/s00204-018-2300-2⟩
Journal articles hal-01863847v1
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Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo

Simon Bucher , Arnaud Tête , Normand Podechard , Marie Liamin , Dounia Le Guillou et al.
Scientific Reports, 2018, 8 (1), pp.5963. ⟨10.1038/s41598-018-24403-1⟩
Journal articles hal-01771620v1

Modulation of metabolizing enzymes by bisphenol a in human and animal models.

Nicolas Quesnot , Simon Bucher , Bernard Fromenty , Marie-Anne Robin
Chemical Research in Toxicology, 2014, 27 (9), pp.1463-73. ⟨10.1021/tx500087p⟩
Journal articles hal-01134758v1
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A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen

Anaïs Michaut , Dounia Le Guillou , Caroline Moreau , Simon Bucher , Mitchell R. Mcgill et al.
Toxicology and Applied Pharmacology, 2016, 292, pp.40-55. ⟨10.1016/j.taap.2015.12.020⟩
Journal articles hal-01255826v1
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Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure

Simon Bucher , Pégah Jalili , Dounia Le Guillou , Karima Begriche , Karine Rondel et al.
Environmental Toxicology, 2017, 32 (3), pp.1024-1036. ⟨10.1002/tox.22301⟩
Journal articles hal-01470709v1

Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells

Nicolas Quesnot , Karine Rondel , Marc Audebert , Sophie Martinais , Denise Glaise et al.
Mutagenesis, 2016, 31 (1), pp.43-50. ⟨10.1093/mutage/gev059⟩
Journal articles hal-01187325v1

Mitochondrialdysfunction in nonalcoholicsteatohepatitis (NASH): are there drugsable to improve it?

Karima Begriche , Laetitia Knockaert , Julie Massart , Marie-Anne Robin , Bernard Fromenty et al.
Drug Discovery Today: Disease Mechanisms, 2009, 6 (1-4), pp.e11-e23. ⟨10.1016/j.ddmec.2009.02.002⟩
Journal articles istex hal-00741749v1

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.

Sébastien Anthérieu , Alexandra Rogue , Bernard Fromenty , André Guillouzo , Marie-Anne Robin et al.
Hepatology, 2011, 53 (6), pp.1895-905. ⟨10.1002/hep.24290⟩
Journal articles hal-00739358v1

Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.

Julie Dumont , Rozenn Jossé , Carine Lambert , Sébastien Anthérieu , Ludovic Le Hegarat et al.
Toxicology and Applied Pharmacology, 2010, 245 (2), pp.256-63. ⟨10.1016/j.taap.2010.03.008⟩
Journal articles istex hal-00533754v1

Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.

Laetitia Knockaert , Bernard Fromenty , Marie-Anne Robin
FEBS Journal, 2011, 278 (22), pp.4252-60. ⟨10.1111/j.1742-4658.2011.08357.x⟩
Journal articles hal-00739827v1
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Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation

Nathalie Poupin , Anne Corlu , Nicolas J. Cabaton , Hélène Dubois-Pot-Schneider , Cécile Canlet et al.
Journal of Proteome Research, 2019, 18 (1), pp.204-216. ⟨10.1021/acs.jproteome.8b00524⟩
Journal articles hal-01937261v1

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.

Karima Begriche , Julie Massart , Marie-Anne Robin , Fabrice Bonnet , Bernard Fromenty et al.
Hepatology, 2013, 58 (4), pp.1497-1507. ⟨10.1002/hep.26226⟩
Journal articles inserm-00814080v1

Alcohol increases tumor necrosis factor α and decreases nuclear factor-κb to activate hepatic apoptosis in genetically obese mice

Marie-Anne Robin , Christine Demeilliers , Angela Sutton , Valérie Paradis , Caroline Maisonneuve et al.
Hepatology, 2005, 42 (6), pp.1280-1290. ⟨10.1002/hep.20949⟩
Journal articles hal-02185522v1

Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.

Claudia Mitchell , Meriem Mahrouf-Yorgov , Alicia Mayeuf , Marie-Anne Robin , Abdellah Mansouri et al.
Laboratory Investigation, 2011, 91 (2), pp.273-82. ⟨10.1038/labinvest.2010.163⟩
Journal articles hal-00740125v1

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

Sébastien Anthérieu , Pamela Bachour-El Azzi , Julie Dumont , Ziad Abdel-Razzak , Christiane Guguen-Guillouzo et al.
Hepatology, 2013, 57 (4), pp.1518-29. ⟨10.1002/hep.26160⟩
Journal articles hal-00865999v1

Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver.

Laetitia Knockaert , Alain Berson , Catherine Ribault , Pierre-Emmanuel Prost , Alain Fautrel et al.
Laboratory Investigation, 2012, 92 (3), pp.396-410. ⟨10.1038/labinvest.2011.193⟩
Journal articles inserm-00864733v1

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.

J. Aubert , Karima Begriche , Laetitia Knockaert , Marie-Anne Robin , Bernard Fromenty et al.
Journal of Bone and Mineral Research, 2011, 35 (10), pp.630-7. ⟨10.1016/j.clinre.2011.04.015⟩
Journal articles istex hal-00739365v1
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Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.

Sébastien Anthérieu , Dounia Le Guillou , Cédric Coulouarn , Karima Begriche , Viviane Trak-Smayra et al.
Toxicology and Applied Pharmacology, 2014, 276 (1), pp.63-72. ⟨10.1016/j.taap.2014.01.019⟩
Journal articles hal-01057872v1

Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.

Camille C Savary , Rozenn Jossé , Arnaud Bruyère , Fabrice Guillet , Marie-Anne Robin et al.
Drug Metabolism and Disposition, 2014, 42 (8), pp.1235-40. ⟨10.1124/dmd.114.057786⟩
Journal articles hal-01128192v1
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Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Karima Begriche , Julie Massart , Marie-Anne Robin , Annie Borgne-Sanchez , Bernard Fromenty et al.
Journal of Hepatology, 2011, 54 (4), pp.773-94. ⟨10.1016/j.jhep.2010.11.006⟩
Journal articles hal-00739371v1

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen.

Laetitia Knockaert , Véronique Descatoire , Nathalie Vadrot , Bernard Fromenty , Marie-Anne Robin et al.
Toxicology in Vitro, 2011, 25 (2), pp.475-84. ⟨10.1016/j.tiv.2010.11.019⟩
Journal articles istex hal-00739823v1