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Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.
Julie Dumont
,
Rozenn Jossé
,
Carine Lambert
,
Sébastien Anthérieu
,
Véronique Laurent
et al.
Journal articles
istex
hal-00742145v1
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Central role of mitochondria in drug-induced liver injury.
Dominique Pessayre
,
Bernard Fromenty
,
Alain Berson
,
Marie-Anne Robin
,
Philippe Lettéron
et al.
Journal articles
hal-00866123v1
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Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
Jacinthe Aubert
,
Karima Begriche
,
Matthieu Delannoy
,
Isabelle Morel
,
Julie Pajaud
et al.
Journal articles
inserm-00864718v1
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Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.
Julie Massart
,
Marie-Anne Robin
,
Fanny Noury
,
Alain Fautrel
,
P. Lettéron
et al.
Journal articles
hal-00740120v1
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Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.
Rozenn Josse
,
Julie Dumont
,
Alain Fautrel
,
Marie-Anne Robin
,
André Guillouzo
et al.
Journal articles
istex
hal-00866033v1
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Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG cell-based biosensors to monitor hepatocyte differentiation, drug metabolism and toxicity
Manuel Vlach
,
Nicolas Quesnot
,
Hélène Dubois-Pot-Schneider
,
Catherine Ribault
,
Yann Verres
et al.
Journal articles
hal-02152870v1
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Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease
Anaïs Michaut
,
Caroline Moreau
,
Marie-Anne Robin
,
Bernard Fromenty
Journal articles
hal-01128195v1
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Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes
Nicolas Quesnot
,
Simon Bucher
,
Christina Gade
,
Manuel Vlach
,
Elise Vene
et al.
Journal articles
hal-01863847v1
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Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo
Simon Bucher
,
Arnaud Tête
,
Normand Podechard
,
Marie Liamin
,
Dounia Le Guillou
et al.
Journal articles
hal-01771620v1
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Modulation of metabolizing enzymes by bisphenol a in human and animal models.
Nicolas Quesnot
,
Simon Bucher
,
Bernard Fromenty
,
Marie-Anne Robin
Journal articles
hal-01134758v1
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A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen
Anaïs Michaut
,
Dounia Le Guillou
,
Caroline Moreau
,
Simon Bucher
,
Mitchell R. Mcgill
et al.
Journal articles
hal-01255826v1
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Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure
Simon Bucher
,
Pégah Jalili
,
Dounia Le Guillou
,
Karima Begriche
,
Karine Rondel
et al.
Journal articles
hal-01470709v1
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Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells
Nicolas Quesnot
,
Karine Rondel
,
Marc Audebert
,
Sophie Martinais
,
Denise Glaise
et al.
Journal articles
hal-01187325v1
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Mitochondrialdysfunction in nonalcoholicsteatohepatitis (NASH): are there drugsable to improve it?
Karima Begriche
,
Laetitia Knockaert
,
Julie Massart
,
Marie-Anne Robin
,
Bernard Fromenty
et al.
Journal articles
istex
hal-00741749v1
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Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.
Sébastien Anthérieu
,
Alexandra Rogue
,
Bernard Fromenty
,
André Guillouzo
,
Marie-Anne Robin
et al.
Journal articles
hal-00739358v1
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Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.
Julie Dumont
,
Rozenn Jossé
,
Carine Lambert
,
Sébastien Anthérieu
,
Ludovic Le Hegarat
et al.
Journal articles
istex
hal-00533754v1
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Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
Laetitia Knockaert
,
Bernard Fromenty
,
Marie-Anne Robin
Journal articles
hal-00739827v1
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Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation
Nathalie Poupin
,
Anne Corlu
,
Nicolas J. Cabaton
,
Hélène Dubois-Pot-Schneider
,
Cécile Canlet
et al.
Journal articles
hal-01937261v1
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Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.
Karima Begriche
,
Julie Massart
,
Marie-Anne Robin
,
Fabrice Bonnet
,
Bernard Fromenty
et al.
Journal articles
inserm-00814080v1
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Alcohol increases tumor necrosis factor α and decreases nuclear factor-κb to activate hepatic apoptosis in genetically obese mice
Marie-Anne Robin
,
Christine Demeilliers
,
Angela Sutton
,
Valérie Paradis
,
Caroline Maisonneuve
et al.
Journal articles
hal-02185522v1
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Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.
Claudia Mitchell
,
Meriem Mahrouf-Yorgov
,
Alicia Mayeuf
,
Marie-Anne Robin
,
Abdellah Mansouri
et al.
Journal articles
hal-00740125v1
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Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
Sébastien Anthérieu
,
Pamela Bachour-El Azzi
,
Julie Dumont
,
Ziad Abdel-Razzak
,
Christiane Guguen-Guillouzo
et al.
Journal articles
hal-00865999v1
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Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver.
Laetitia Knockaert
,
Alain Berson
,
Catherine Ribault
,
Pierre-Emmanuel Prost
,
Alain Fautrel
et al.
Journal articles
inserm-00864733v1
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Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.
J. Aubert
,
Karima Begriche
,
Laetitia Knockaert
,
Marie-Anne Robin
,
Bernard Fromenty
et al.
Journal articles
istex
hal-00739365v1
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Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.
Sébastien Anthérieu
,
Dounia Le Guillou
,
Cédric Coulouarn
,
Karima Begriche
,
Viviane Trak-Smayra
et al.
Journal articles
hal-01057872v1
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Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.
Camille C Savary
,
Rozenn Jossé
,
Arnaud Bruyère
,
Fabrice Guillet
,
Marie-Anne Robin
et al.
Journal articles
hal-01128192v1
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Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.
Karima Begriche
,
Julie Massart
,
Marie-Anne Robin
,
Annie Borgne-Sanchez
,
Bernard Fromenty
et al.
Journal articles
hal-00739371v1
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Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen.
Laetitia Knockaert
,
Véronique Descatoire
,
Nathalie Vadrot
,
Bernard Fromenty
,
Marie-Anne Robin
et al.
Journal articles
istex
hal-00739823v1
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