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cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.
Xavier Fant
,
Emilie Durieu
,
Gaëtan Chicanne
,
Bernard Payrastre
,
Diego Sbrissa
et al.
Journal articles
inserm-01012086v1
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Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
Mansour Debdab
,
François Carreaux
,
Steven Renault
,
Meera Soundararajan
,
Oleg Fedorov
et al.
Journal articles
hal-00870007v1
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An efficient approach to dispacamide A and its derivatives.
Solène Guihéneuf
,
Ludovic Paquin
,
François Carreaux
,
Emilie Durieu
,
Laurent Meijer
et al.
Journal articles
hal-00870469v1
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Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors
Tania Tahtouh
,
Emilie Durieu
,
Benoit Villiers
,
Celine Bruyere
,
Thu Lan Nguyen
et al.
Journal articles
hal-03512536v1
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases
Nadège Loaëc
,
Eletta Attanasio
,
Benoît Villiers
,
Emilie Durieu
,
Tania Tahtouh
et al.
Journal articles
hal-01640115v1
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Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases.
Wacothon Karime Coulibaly
,
Ludovic Paquin
,
Anoubilé Bénie
,
Yves-Alain Bekro
,
Emilie Durieu
et al.
Journal articles
istex
hal-00813182v1
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A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene- 1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
Khadidja Bourahla
,
Ludovic Paquin
,
Olivier Lozach
,
Laurent Meijer
,
François Carreaux
et al.
Journal articles
hal-00870301v1
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Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.
Mansour Debdab
,
Stéven Renault
,
Olivier Lozach
,
Laurent Meijer
,
Ludovic Paquin
et al.
Journal articles
istex
hal-00869769v1
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Dérivés d'imidazolones, procédé de préparation et applications biologiques.
J.P. Bazureau
,
François Carreaux
,
Stéven Renault
,
Laurent Meijer
,
Olivier Lozach
et al.
Patent n° : FR 291 9608 (A1). 2009
Patents
hal-00411458v1
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Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects
Solene Guiheneuf
,
Ludovic Paquin
,
Francois Carreaux
,
Emilie Durieu
,
Helene Benedetti
et al.
Journal articles
hal-01114583v1
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Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Tania Tahtouh
,
Jonathan M. Elkins
,
Panagis Filippakopoulos
,
Meera Soundararajan
,
Guillaume Burgy
et al.
Journal articles
hal-00870472v1
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30th Franco-Belgian conference of pharmacochemistry
Charlotte Bouckaert
,
Eric Goffin
,
Sebastien Dilly
,
Julien Hanson
,
Lionel Pochet
et al.
Journal articles
hal-02141338v1
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An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives
Abdelmounaim Safer
,
Mustapha Rahmouni
,
François Carreaux
,
Ludovic Paquin
,
Olivier Lozach
et al.
Journal articles
hal-00869920v1
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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
Benoit Souchet
,
Mickael Audrain
,
Jean Marie Billard
,
Julien Dairou
,
Romain Fol
et al.
Journal articles
hal-02324924v1
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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
Thu Lan Nguyen
,
Arnaud Duchon
,
Antigoni Manousopoulou
,
Nadège Loaëc
,
Benoît Villiers
et al.
Journal articles
hal-01862465v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors
Amélie Bruel
,
Romain Bénéteau
,
Mylène Chabanne
,
Olivier Lozach
,
Rémy Le Guevel
et al.
Journal articles
hal-01086026v1
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Exploring the Synthesis of New 1-(4-Substitutedphenylamino) imidazo[1,5-a]indol-3-one Derivatives as Cyclized Analogs of Leucettines
Guillaume Burgy
,
Emmanuelle Limanton
,
François Carreaux
,
Emilie Durieu
,
Laurent Meijer
et al.
Journal articles
hal-01116022v1
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Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.
Guillaume Burgy
,
Tania Tahtouh
,
Emilie Durieu
,
Béatrice Foll-Josselin
,
Emmanuelle Limanton
et al.
Journal articles
hal-00822733v1
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Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors
Aziz Ouach
,
Rajâa Boulahjar
,
Christine Vala
,
Stéphane Bourg
,
Pascal Bonnet
et al.
Journal articles
hal-01295635v1
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An efficient method for the preparation of new analogs of Leucettamine B under solvent-free microwave irradiation.
Mansour Debdab
,
Stéven Renault
,
Samar Eid
,
Olivier Lozach
,
Laurent Meijer
et al.
Heterocycles, 2009, pp.1191-1203
Journal articles
hal-00411456v1
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Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.
Wacothon Karime Coulibaly
,
Ludovic Paquin
,
Anoubilé Bénié
,
Yves-Alain Bekro
,
Emilie Durieux
et al.
Journal articles
inserm-00864810v1
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New 5-ylidene rhodanine derivatives based on the dispacamide A model.
Solène Guihéneuf
,
Ludovic Paquin
,
François Carreaux
,
Emilie Durieu
,
Thierry Roisnel
et al.
Journal articles
hal-01017003v1
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Novel Tetrahydropyrido[1,2- a ]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts
Rajâa Boulahjar
,
Aziz Ouach
,
Chiurato Matteo
,
Stéphane Bourg
,
Myriam Ravache
et al.
Journal articles
hal-02904751v1
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Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8
Katy Billot
,
Charlène Coquil
,
Benoît Villiers
,
Béatrice Josselin-Foll
,
Nathalie Desban
et al.
Journal articles
hal-01738526v1
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Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts
Rajâa Boulahjar
,
Aziz Ouach
,
Chiurato Matteo
,
Stéphane Bourg
,
Myriam Ravache
et al.
Journal of Medicinal Chemistry, 2012, 55, pp.9589-9606
Journal articles
hal-00785213v1
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Synthesis and kinase inhibitory activity of novel substituted indigoids.
Anne Beauchard
,
Hélène Laborie
,
Hervé Rouillard
,
Olivier Lozach
,
Yoan Ferandin
et al.
Journal articles
istex
hal-00416031v1
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Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A
Khadidja Bourahla
,
Solène Guihéneuf
,
Emmanuelle Limanton
,
Ludovic Paquin
,
Rémy Le Guével
et al.
Journal articles
hal-03467664v1
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