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authFullName_s : Laurent Meijer

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Xavier Fant , Emilie Durieu , Gaëtan Chicanne , Bernard Payrastre , Diego Sbrissa et al.
Molecular Pharmacology, 2014, 85 (3), pp.441-50. ⟨10.1124/mol.113.090837⟩
Journal articles inserm-01012086v1

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Mansour Debdab , François Carreaux , Steven Renault , Meera Soundararajan , Oleg Fedorov et al.
Journal of Medicinal Chemistry, 2011, 54 (12), pp.4172-86. ⟨10.1021/jm200274d⟩
Journal articles hal-00870007v1

An efficient approach to dispacamide A and its derivatives.

Solène Guihéneuf , Ludovic Paquin , François Carreaux , Emilie Durieu , Laurent Meijer et al.
Organic & Biomolecular Chemistry, 2012, 10 (5), pp.978-87. ⟨10.1039/c1ob06161e⟩
Journal articles hal-00870469v1

Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors

Tania Tahtouh , Emilie Durieu , Benoit Villiers , Celine Bruyere , Thu Lan Nguyen et al.
Journal of Medicinal Chemistry, 2022, 65 (2), pp.1396-1417. ⟨10.1021/acs.jmedchem.1c01141⟩
Journal articles hal-03512536v1
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Nadège Loaëc , Eletta Attanasio , Benoît Villiers , Emilie Durieu , Tania Tahtouh et al.
Marine drugs, 2017, 15 (10), pp.316 -. ⟨10.3390/md15100316⟩
Journal articles hal-01640115v1

Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases.

Wacothon Karime Coulibaly , Ludovic Paquin , Anoubilé Bénie , Yves-Alain Bekro , Emilie Durieu et al.
European Journal of Medicinal Chemistry, 2012, 58, pp.581-90. ⟨10.1016/j.ejmech.2012.08.044⟩
Journal articles istex hal-00813182v1
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A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene- 1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

Khadidja Bourahla , Ludovic Paquin , Olivier Lozach , Laurent Meijer , François Carreaux et al.
Molecules, 2011, 16, pp.7377-7390. ⟨10.3390/molecules16097377⟩
Journal articles hal-00870301v1

Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.

Mansour Debdab , Stéven Renault , Olivier Lozach , Laurent Meijer , Ludovic Paquin et al.
European Journal of Medicinal Chemistry, 2010, 45 (2), pp.805-10. ⟨10.1016/j.ejmech.2009.10.009⟩
Journal articles istex hal-00869769v1

Dérivés d'imidazolones, procédé de préparation et applications biologiques.

J.P. Bazureau , François Carreaux , Stéven Renault , Laurent Meijer , Olivier Lozach et al.
Patent n° : FR 291 9608 (A1). 2009
Patents hal-00411458v1

Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects

Solene Guiheneuf , Ludovic Paquin , Francois Carreaux , Emilie Durieu , Helene Benedetti et al.
Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩
Journal articles hal-01114583v1

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tania Tahtouh , Jonathan M. Elkins , Panagis Filippakopoulos , Meera Soundararajan , Guillaume Burgy et al.
Journal of Medicinal Chemistry, 2012, 55 (21), pp.9312-30. ⟨10.1021/jm301034u⟩
Journal articles hal-00870472v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet et al.
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Journal articles hal-02141338v1

An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

Abdelmounaim Safer , Mustapha Rahmouni , François Carreaux , Ludovic Paquin , Olivier Lozach et al.
Chemical Papers, 2011, 65 (3), pp.332-337. ⟨10.2478/s11696-010-0104-9⟩
Journal articles hal-00869920v1
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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Benoit Souchet , Mickael Audrain , Jean Marie Billard , Julien Dairou , Romain Fol et al.
Acta Neuropathologica Communications, 2019, 7 (1), pp.46. ⟨10.1186/s40478-019-0678-6⟩
Journal articles hal-02324924v1
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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Thu Lan Nguyen , Arnaud Duchon , Antigoni Manousopoulou , Nadège Loaëc , Benoît Villiers et al.
Disease Models & Mechanisms, 2018, 11 (9), pp.dmm035634. ⟨10.1242/dmm.035634⟩
Journal articles hal-01862465v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

Amélie Bruel , Romain Bénéteau , Mylène Chabanne , Olivier Lozach , Rémy Le Guevel et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩
Journal articles hal-01086026v1
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Exploring the Synthesis of New 1-(4-Substitutedphenylamino) imidazo[1,5-a]indol-3-one Derivatives as Cyclized Analogs of Leucettines

Guillaume Burgy , Emmanuelle Limanton , François Carreaux , Emilie Durieu , Laurent Meijer et al.
Journal of Applied Pharmaceutical Science, 2014, 4 (6), pp.25 - 32. ⟨10.7324/JAPS.2014.40604⟩
Journal articles hal-01116022v1

Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.

Guillaume Burgy , Tania Tahtouh , Emilie Durieu , Béatrice Foll-Josselin , Emmanuelle Limanton et al.
European Journal of Medicinal Chemistry, 2013, 62, pp.728-37. ⟨10.1016/j.ejmech.2013.01.035⟩
Journal articles hal-00822733v1

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

Aziz Ouach , Rajâa Boulahjar , Christine Vala , Stéphane Bourg , Pascal Bonnet et al.
European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
Journal articles hal-01295635v1

An efficient method for the preparation of new analogs of Leucettamine B under solvent-free microwave irradiation.

Mansour Debdab , Stéven Renault , Samar Eid , Olivier Lozach , Laurent Meijer et al.
Heterocycles, 2009, pp.1191-1203
Journal articles hal-00411456v1
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Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.

Wacothon Karime Coulibaly , Ludovic Paquin , Anoubilé Bénié , Yves-Alain Bekro , Emilie Durieux et al.
Scientia Pharmaceutica, 2012, 80 (4), pp.825-36. ⟨10.3797/scipharm.1206-04⟩
Journal articles inserm-00864810v1
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New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Solène Guihéneuf , Ludovic Paquin , François Carreaux , Emilie Durieu , Thierry Roisnel et al.
Molecular Diversity, 2014, 18 (2), pp.375-88. ⟨10.1007/s11030-014-9509-7⟩
Journal articles hal-01017003v1

Novel Tetrahydropyrido[1,2- a ]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

Rajâa Boulahjar , Aziz Ouach , Chiurato Matteo , Stéphane Bourg , Myriam Ravache et al.
Journal of Medicinal Chemistry, 2012, 55 (22), pp.9589-9606. ⟨10.1021/jm3008536⟩
Journal articles hal-02904751v1

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

Katy Billot , Charlène Coquil , Benoît Villiers , Béatrice Josselin-Foll , Nathalie Desban et al.
AJP Renal Physiology, 2018, ⟨10.1152/ajprenal.00489.2017⟩
Journal articles hal-01738526v1

Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

Rajâa Boulahjar , Aziz Ouach , Chiurato Matteo , Stéphane Bourg , Myriam Ravache et al.
Journal of Medicinal Chemistry, 2012, 55, pp.9589-9606
Journal articles hal-00785213v1

Synthesis and kinase inhibitory activity of novel substituted indigoids.

Anne Beauchard , Hélène Laborie , Hervé Rouillard , Olivier Lozach , Yoan Ferandin et al.
Bioorganic and Medicinal Chemistry, 2009, 17 (17), pp.6257-63. ⟨10.1016/j.bmc.2009.07.051⟩
Journal articles istex hal-00416031v1
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Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A

Khadidja Bourahla , Solène Guihéneuf , Emmanuelle Limanton , Ludovic Paquin , Rémy Le Guével et al.
Pharmaceuticals, 2021, 14 (11), pp.1086-1117. ⟨10.3390/ph14111086⟩
Journal articles hal-03467664v1