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authFullName_s : Ali Hachem

Synthesis of Chroman-4-ones with gem-Difluoroalkyl Side Chains in Position 2

Assaad Nasr El Dine , Olivier Tasseau , Danielle Grée , Thierry Roisnel , Ali Khalaf et al.
SYNLETT, 2014, 25 (17), pp.2451-2454. ⟨10.1055/s-0034-1378579⟩
Journal articles hal-01114421v1

Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains

Ali Soulieman , Nicolas Gouault , Thierry Roisnel , Frédéric Justaud , Joël Boustie et al.
SYNLETT, 2019, 30 (20), pp.2258-2262. ⟨10.1055/s-0039-1690715⟩
Journal articles hal-02438548v1
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Synthesis of Novel Cyclic Nitrones withgem-Difluoroalkyl Side Chains Through Cascade Reactions

Ali Soulieman , Rima Ibrahim , Zeinab Barakat , Nicolas Gouault , Thierry Roisnel et al.
European Journal of Organic Chemistry, 2020, 2020 (35), pp.5741-5751. ⟨10.1002/ejoc.202000972⟩
Journal articles hal-02957740v1

Asymmetric Organocatalytic 1,4-Addition Reactions Starting from Enals with gem-Difluoroalkyl Side Chains

Ali Khalaf , Danielle Gree , Hassan Abdallah , Nada Jaber , Ali Hachem et al.
European Journal of Organic Chemistry, 2013, 4, pp.653-657. ⟨10.1002/ejoc.201201427⟩
Journal articles istex hal-00819314v1
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One-Pot Reaction between N -Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles

Tourin Bzeih , Kena Zhang , Ali Khalaf , Ali Hachem , Mouad Alami et al.
Journal of Organic Chemistry, 2019, 84 (1), pp.228-238. ⟨10.1021/acs.joc.8b02623⟩
Journal articles hal-02414153v1
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Recent Developments in the Meyer-Schuster Rearrangement

Frédéric Justaud , Ali Hachem , René Grée
European Journal of Organic Chemistry, 2021, 2021 (4), pp.514-542. ⟨10.1002/ejoc.202001494⟩
Journal articles hal-03269552v1
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gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

Abeer J. Ayoub , Layal Hariss , Nehme El-Hachem , Ghewa A. El-Achkar , Sandra E Ghayad et al.
BMC Chemistry, 2019, 13 (1), ⟨10.1186/s13065-019-0640-5⟩
Journal articles hal-02391905v1

A General Approach to Various Five- and Six-Membered gem-Difluoroheterocycles Application to the Synthesis of Fluorinated Analogues of Sedamine

Layal Hariss , Rima Ibrahim , Nada Jaber , Thierry Roisnel , René Grée et al.
European Journal of Organic Chemistry, 2018, 2018 (27-28), pp.3782-3791. ⟨10.1002/ejoc.201800371⟩
Journal articles hal-01861423v1
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Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

Hippolyte Paysant , Siham Hedir , Frédéric Justaud , Louis Bastien Weiswald , Assaad Nasr El Dine et al.
Organic & Biomolecular Chemistry, 2021, 19 (41), pp.8968-8987. ⟨10.1039/d1ob01521d⟩
Journal articles hal-03414007v1

Synthesis of Fluorine-Containing Exoalkylidene β-Lactams

Assaad Nasr El Dine , Danielle Grée , Thierry Roisnel , Elsa Caytan , Ali Hachem et al.
European Journal of Organic Chemistry, 2016, 2016 (3), pp.556-561. ⟨10.1002/ejoc.201501347⟩
Journal articles istex hal-01242905v1

Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

Assaad Nasr El Dine , Ali Khalaf , Danielle Gree , Olivier Tasseau , Fares Fares et al.
Beilstein Journal of Organic Chemistry, 2013, 9, pp.1943-1948. ⟨10.3762/bjoc.9.230⟩
Journal articles hal-00871797v1

Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans

Layal Hariss , Kamal H. Bouhadir , Thierry Roisnel , René Grée , Ali Hachem et al.
SYNLETT, 2017, 28 (2), pp.195--200. ⟨10.1055/s-0036-1588623⟩
Journal articles hal-01500399v1

A new flexible strategy for the synthesis of gem-difluoro-bisarylic derivatives and heterocyclic analogues

Ali Khalaf , Danielle Gree , Hassan Abdallah , Nada Jaber , Ali Hachem et al.
Tetrahedron, 2011, 67 (21), pp.3881-3886. ⟨10.1016/j.tet.2011.03.073⟩
Journal articles istex hal-00843381v1
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Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

Layal Hariss , Kamal Bou Hadir , Mirvat El-Masri , Thierry Roisnel , René Grée et al.
Beilstein Journal of Organic Chemistry, 2017, 13, pp.2115-2121. ⟨10.3762/bjoc.13.208⟩
Journal articles hal-01631917v1

New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity.

Taghreed Hirz , Ali Khalaf , Nehme El-Hachem , May F. Mrad , Hassan Abdallah et al.
Chemistry Central Journal, 2012, 6 (1), pp.152. ⟨10.1186/1752-153X-6-152⟩
Journal articles hal-00813133v1

Erratum to: Preparation of new gem-difluoro heterocyclic-fused 1,2,3-triazole derivatives (vol 60, pg 292, 2019)

Layal Hariss , Zeinab Barakat , Fares Fares , Thierry Roisnel , René Grée et al.
Tetrahedron Letters, 2019, 60 (10), pp.754-754. ⟨10.1016/j.tetlet.2019.01.056⟩
Journal articles hal-02303420v1
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A new direct synthesis of α-methylene- and α-alkylidene-β-lactams

Marwa Hussein , Assaad Nasr El Dine , Fares Fares , Vincent Dorcet , Ali Hachem et al.
Tetrahedron Letters, 2016, 57 (18), pp.1990-1993. ⟨10.1016/j.tetlet.2016.03.083⟩
Journal articles hal-01295513v1

A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis possible role of miRNA-125a-5p and miRNA-181a-5p

Rania El Majzoub , Mohammad Fayyad-Kazan , Assaad Nasr El Dine , Rawan Makki , Eva Hamade et al.
Genes and Genomics, 2019, 41 (12), pp.1431-1443. ⟨10.1007/s13258-019-00866-y⟩
Journal articles hal-02307029v1