<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05420585</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T00:52:06+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Interaction of bioactive glasses with fibrinogen protein. Effect of porosity and surface modification</title>
            <author role="crp">
              <persName>
                <forename type="first">Anita</forename>
                <surname>Lucas</surname>
              </persName>
              <email type="md5">bea8b2e077482dbdd64f095c3a866347</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="string">anita-lucas</idno>
              <idno type="idhal" notation="numeric">1201137</idno>
              <idno type="halauthorid" notation="string">801525-1201137</idno>
              <affiliation ref="#struct-194938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">T.</forename>
                <surname>Berthelot</surname>
              </persName>
              <idno type="idhal" notation="numeric">1624983</idno>
              <idno type="halauthorid" notation="string">419264-1624983</idno>
              <idno type="ORCID">https://orcid.org/0009-0004-8577-4546</idno>
              <affiliation ref="#struct-194938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Lebreton</surname>
              </persName>
              <idno type="halauthorid">160131-0</idno>
              <affiliation ref="#struct-194938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Jauneau</surname>
              </persName>
              <idno type="idhal" notation="numeric">1624984</idno>
              <idno type="halauthorid" notation="string">3948393-1624984</idno>
              <idno type="ORCID">https://orcid.org/0009-0005-9362-262X</idno>
              <affiliation ref="#struct-194938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D.</forename>
                <surname>Brezulier</surname>
              </persName>
              <email type="md5">11863218ccc98bd4f19cd6398cedd6b1</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="string">damienbrezulier</idno>
              <idno type="idhal" notation="numeric">1025383</idno>
              <idno type="halauthorid" notation="string">2611152-1025383</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1519-9943</idno>
              <affiliation ref="#struct-301327"/>
              <affiliation ref="#struct-194938"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Soizic</forename>
                <surname>Chevance</surname>
              </persName>
              <email type="md5">3993da651cf605c59401166bc4e66eac</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="string">soizic-chevance</idno>
              <idno type="idhal" notation="numeric">751879</idno>
              <idno type="halauthorid" notation="string">41938-751879</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAC-4249-2019</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9699-5943</idno>
              <idno type="IDREF">https://www.idref.fr/083597751</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAC-4249-2019</idno>
              <affiliation ref="#struct-194938"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder>The authors of this article would like to acknowledge the SSIM platform of Biosit (UAR 3480 CNRS- US18 Inserm, Université de Rennes) for access to UV–Vis and CD analyses, and the “Institut des Sciences Chimiques de Rennes” (ISCR, UMR CNRS 6226 - Université de Rennes) for financial support.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-12-17 10:15:44</date>
              <date type="whenModified">2025-12-19 03:11:21</date>
              <date type="whenReleased">2025-12-17 10:15:45</date>
              <date type="whenProduced">2026-01</date>
              <date type="whenEndEmbargoed">2025-12-17</date>
              <ref type="file" target="https://univ-rennes.hal.science/hal-05420585v1/document">
                <date notBefore="2025-12-17"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://univ-rennes.hal.science/hal-05420585v1/file/1-s2.0-S0272884225058602-main.pdf" id="file-5420594-4639091">
                <date notBefore="2025-12-17"/>
              </ref>
              <ref type="annex" n="0" target="https://univ-rennes.hal.science/hal-05420585v1/file/1-s2.0-S0272884225058602-mmc1.pdf" id="file-5420594-4639093">
                <date notBefore="2025-12-17"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05420585</idno>
            <idno type="halUri">https://univ-rennes.hal.science/hal-05420585</idno>
            <idno type="halBibtex">lucas:hal-05420585</idno>
            <idno type="halRefHtml">&lt;i&gt;Ceramics International&lt;/i&gt;, 2026, 52 (1), pp.618-626. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ceramint.2025.11.361"&gt;&amp;#x27E8;10.1016/j.ceramint.2025.11.361&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Ceramics International, 2026, 52 (1), pp.618-626. &amp;#x27E8;10.1016/j.ceramint.2025.11.361&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5420594-4639091"/><ref corresp="#file-5420594-4639093"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INSA-RENNES">Institut National des Sciences Appliquées de Rennes</idno>
            <idno type="stamp" n="ENSC-RENNES">Ecole Nationale Supérieure de Chimie de Rennes</idno>
            <idno type="stamp" n="ISCR">INSTITUT DES SCIENCES CHIMIQUES DE RENNES</idno>
            <idno type="stamp" n="SCR_VC" corresp="ISCR">Verres et Céramiques</idno>
            <idno type="stamp" n="SCR_ICMV" corresp="ISCR">Ingénierie Chimique et Molécules pour le Vivant</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="CIC">CIC-Rennes</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="UR1-SPM">Université de Rennes 1 - UFR Sciences et Propriétés de la Matière</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-UFR-SPM">UFR SPM Sciences et Propriétés de la Matière</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="ISCR-CORINT">Chimie ORganique &amp; INTerfaces</idno>
            <idno type="stamp" n="UR1-SDLM">UR1 - publications SDLM</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="IVER">Institut des verres</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="ISCR-CORINT1" corresp="ISCR">ISCR-CORINT (prénoms complets)</idno>
            <idno type="stamp" n="UR1-MMS">Pôle UnivRennes - Matériaux</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Interaction of bioactive glasses with fibrinogen protein. Effect of porosity and surface modification</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Anita</forename>
                    <surname>Lucas</surname>
                  </persName>
                  <email type="md5">bea8b2e077482dbdd64f095c3a866347</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="string">anita-lucas</idno>
                  <idno type="idhal" notation="numeric">1201137</idno>
                  <idno type="halauthorid" notation="string">801525-1201137</idno>
                  <affiliation ref="#struct-194938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">T.</forename>
                    <surname>Berthelot</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1624983</idno>
                  <idno type="halauthorid" notation="string">419264-1624983</idno>
                  <idno type="ORCID">https://orcid.org/0009-0004-8577-4546</idno>
                  <affiliation ref="#struct-194938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Lebreton</surname>
                  </persName>
                  <idno type="halauthorid">160131-0</idno>
                  <affiliation ref="#struct-194938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Jauneau</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1624984</idno>
                  <idno type="halauthorid" notation="string">3948393-1624984</idno>
                  <idno type="ORCID">https://orcid.org/0009-0005-9362-262X</idno>
                  <affiliation ref="#struct-194938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D.</forename>
                    <surname>Brezulier</surname>
                  </persName>
                  <email type="md5">11863218ccc98bd4f19cd6398cedd6b1</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="string">damienbrezulier</idno>
                  <idno type="idhal" notation="numeric">1025383</idno>
                  <idno type="halauthorid" notation="string">2611152-1025383</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1519-9943</idno>
                  <affiliation ref="#struct-301327"/>
                  <affiliation ref="#struct-194938"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Soizic</forename>
                    <surname>Chevance</surname>
                  </persName>
                  <email type="md5">3993da651cf605c59401166bc4e66eac</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="string">soizic-chevance</idno>
                  <idno type="idhal" notation="numeric">751879</idno>
                  <idno type="halauthorid" notation="string">41938-751879</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAC-4249-2019</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9699-5943</idno>
                  <idno type="IDREF">https://www.idref.fr/083597751</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAC-4249-2019</idno>
                  <affiliation ref="#struct-194938"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11588</idno>
                <idno type="issn">0272-8842</idno>
                <title level="j">Ceramics International</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">52</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">618-626</biblScope>
                  <date type="datePub">2026-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ceramint.2025.11.361</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Fibrinogen</term>
                <term xml:lang="en">Protein interaction</term>
                <term xml:lang="en">Surface silanization</term>
                <term xml:lang="en">Ordered porosity</term>
                <term xml:lang="en">Bioactive glass</term>
                <term xml:lang="en">Sol-gel</term>
              </keywords>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Bioactive glasses are of great interest because of their osteostimulative effects and their intimate bond with bone tissue. Their porosity structuring and surface modification also offer opportunities for controlled adsorption, and further controlled release, of active molecules. These new textural properties and chemical surface modifications undoubtedly have an impact on their interaction with blood proteins. In the present work, we investigate the influence of two parameters, together or separately, mesostructuring porosity and surface modification by silanization, on the interactions of a sol-gel derived bioactive glass (92S6) with the blood protein fibrinogen. Results indicate first that the ordered porosity significantly favors the fibrinogen adsorption at the glass surface. On the other hand, surface silanization induces systematically a delayed adsorption of fibrinogen for at least 8 h. After this period of inhibition of protein adsorption, the protein is better adsorbed on silanized glasses surfaces comparatively to unsilanized surfaces. This effect is particularly noticeable when the glass has no mesostructured porosity. In the case of mesostructured porosity, the surface silanization has a minor impact on the adsorbed quantity of protein after 48 h, the protein adsorption being more influenced by the mesostructured porosity. The study also highlights that a modification of the protein conformation occurs when its approaches the glass surface. This modification is not related to ions release in the medium but really related to surface contact. Additionally, the study shows that the strong fibrinogen adsorption is not associated to the creation of covalent bond between fibrinogen and glass surface but due to a reversible electrostatic interaction.The mesostructured porosity and surface silanization offer new opportunities for tunable properties of the 92S6 bioactive glass.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-194938" status="VALID">
          <idno type="IdRef">161775241</idno>
          <idno type="ISNI">0000 0004 0385 6584</idno>
          <idno type="RNSR">200612270R</idno>
          <idno type="ROR">https://ror.org/00adwkx90</idno>
          <idno type="Wikidata">Q30261343</idno>
          <orgName>Institut des Sciences Chimiques de Rennes</orgName>
          <orgName type="acronym">ISCR</orgName>
          <date type="start">2006-01-01</date>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu - Bât. 10 Avenue du Général Leclerc 35042 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://iscr.univ-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-117606" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300373" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR6226" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-117606" status="VALID">
          <idno type="ROR">https://ror.org/04xaa4j22</idno>
          <orgName>Institut National des Sciences Appliquées - Rennes</orgName>
          <orgName type="acronym">INSA Rennes</orgName>
          <desc>
            <address>
              <addrLine>20, avenue des Buttes de Coësmes - CS 70839 - 35708 Rennes cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300373" status="VALID">
          <idno type="ROR">https://ror.org/01h0ffh48</idno>
          <orgName>Ecole Nationale Supérieure de Chimie de Rennes</orgName>
          <orgName type="acronym">ENSCR</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>