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Journal Articles Nature Year : 2024

Population genomics of post-glacial western Eurasia

Morten Allentoft (1, 2) , Martin Sikora (1) , Alba Refoyo-Martínez , Evan Irving-Pease , Anders Fischer , William Barrie , Andrés Ingason (3) , Jesper Stenderup , Karl-Göran Sjögren , Alice Pearson , Bárbara Sousa da Mota , Bettina Schulz Paulsson (4) , Alma Halgren , Ruairidh Macleod , Marie Louise Schjellerup Jørkov , Fabrice Demeter (5) , Lasse Sørensen , Poul Otto Nielsen , Rasmus Henriksen , Tharsika Vimala (6) , Hugh Mccoll , Ashot Margaryan , Melissa Ilardo , Andrew Vaughn , Morten Fischer Mortensen , Anne Birgitte Nielsen , Mikkel Ulfeldt Hede , Niels Nørkjær Johannsen , Peter Rasmussen , Lasse Vinner , Gabriel Renaud , Aaron Stern , Theis Zetner Trolle Jensen , Gabriele Scorrano , Hannes Schroeder , Per Lysdahl , Abigail Daisy Ramsøe , Andrei Skorobogatov , Andrew Joseph Schork , Anders Rosengren , Anthony Ruter , Alan Outram , Aleksey Timoshenko , Alexandra Buzhilova , Alfredo Coppa , Alisa Zubova , Ana Maria Silva , Anders Hansen , Andrey Gromov , Andrey Logvin , Anne Birgitte Gotfredsen , Bjarne Henning Nielsen , Borja González-Rabanal , Carles Lalueza-Fox , Catriona Mckenzie , Charleen Gaunitz , Concepción Blasco , Corina Liesau , Cristina Martinez-Labarga , Dmitri Pozdnyakov , David Cuenca-Solana (7) , David Lordkipanidze , Dmitri En'Shin , Domingo Salazar-García , T Douglas Price , Dušan Borić , Elena Kostyleva , Elizaveta Veselovskaya , Emma Usmanova , Enrico Cappellini , Erik Brinch Petersen , Esben Kannegaard , Francesca Radina , Fulya Eylem Yediay , Henri Duday (8) , Igor Gutiérrez-Zugasti , Ilya Merts , Inna Potekhina , Irina Shevnina , Isin Altinkaya , Jean Guilaine (9) , Jesper Hansen , Joan Emili Aura Tortosa , João Zilhão , Jorge Vega , Kristoffer Buck Pedersen , Krzysztof Tunia , Lei Zhao , Liudmila Mylnikova , Lars Larsson , Laure Metz (10) , Levon Yepiskoposyan , Lisbeth Pedersen , Lucia Sarti , Ludovic Orlando (11) , Ludovic Slimak (11) , Lutz Klassen , Malou Blank , Manuel González-Morales , Mara Silvestrini , Maria Vretemark , Marina Nesterova , Marina Rykun , Mario Federico Rolfo , Marzena Szmyt , Marcin Przybyła , Mauro Calattini , Mikhail Sablin , Miluše Dobisíková , Morten Meldgaard , Morten Johansen , Natalia Berezina , Nick Card , Nikolai Saveliev , Olga Poshekhonova , Olga Rickards , Olga Lozovskaya , Olivér Gábor , Otto Christian Uldum , Paola Aurino , Pavel Kosintsev , Patrice Courtaud , Patricia Ríos , Peder Mortensen , Per Lotz , Per Persson , Pernille Bangsgaard , Peter de Barros Damgaard , Peter Vang Petersen , Pilar Prieto Martinez , Piotr Włodarczak , Roman Smolyaninov , Rikke Maring , Roberto Menduiña , Ruben Badalyan , Rune Iversen , Ruslan Turin , Sergey Vasilyev , Sidsel Wåhlin , Svetlana Borutskaya , Svetlana Skochina , Søren Anker Sørensen , Søren Andersen , Thomas Jørgensen , Yuri Serikov , Vyacheslav Molodin , Vaclav Smrcka , Victor Merts , Vivek Appadurai , Vyacheslav Moiseyev , Yvonne Magnusson , Kurt Kjær , Niels Lynnerup , Daniel Lawson , Peter Sudmant , Simon Rasmussen , Thorfinn Sand Korneliussen , Richard Durbin , Rasmus Nielsen , Olivier Delaneau , Thomas Werge , Fernando Racimo , Kristian Kristiansen , Eske Willerslev (12, 1)
Alba Refoyo-Martínez
  • Function : Author
Evan Irving-Pease
Anders Fischer
William Barrie
  • Function : Author
Jesper Stenderup
  • Function : Author
Karl-Göran Sjögren
Alice Pearson
  • Function : Author
Bárbara Sousa da Mota
  • Function : Author
Alma Halgren
Ruairidh Macleod
  • Function : Author
Marie Louise Schjellerup Jørkov
Lasse Sørensen
  • Function : Author
Poul Otto Nielsen
  • Function : Author
Rasmus Henriksen
Hugh Mccoll
Ashot Margaryan
Melissa Ilardo
  • Function : Author
Andrew Vaughn
  • Function : Author
Morten Fischer Mortensen
Anne Birgitte Nielsen
Mikkel Ulfeldt Hede
  • Function : Author
Niels Nørkjær Johannsen
  • Function : Author
Peter Rasmussen
  • Function : Author
Lasse Vinner
  • Function : Author
Gabriel Renaud
Aaron Stern
  • Function : Author
Theis Zetner Trolle Jensen
  • Function : Author
Gabriele Scorrano
Hannes Schroeder
Per Lysdahl
  • Function : Author
Abigail Daisy Ramsøe
  • Function : Author
Andrei Skorobogatov
Andrew Joseph Schork
  • Function : Author
Anders Rosengren
Anthony Ruter
  • Function : Author
Alan Outram
Aleksey Timoshenko
Alexandra Buzhilova
Alfredo Coppa
Alisa Zubova
  • Function : Author
Ana Maria Silva
Anders Hansen
Andrey Gromov
  • Function : Author
Andrey Logvin
  • Function : Author
Anne Birgitte Gotfredsen
Bjarne Henning Nielsen
  • Function : Author
Borja González-Rabanal
Carles Lalueza-Fox
Catriona Mckenzie
Charleen Gaunitz
  • Function : Author
Concepción Blasco
  • Function : Author
Corina Liesau
  • Function : Author
Cristina Martinez-Labarga
Dmitri Pozdnyakov
  • Function : Author
David Lordkipanidze
  • Function : Author
Dmitri En'Shin
  • Function : Author
Domingo Salazar-García
  • Function : Author
T Douglas Price
  • Function : Author
Dušan Borić
  • Function : Author
Elena Kostyleva
  • Function : Author
Elizaveta Veselovskaya
Emma Usmanova
  • Function : Author
Enrico Cappellini
Erik Brinch Petersen
  • Function : Author
Esben Kannegaard
  • Function : Author
Francesca Radina
  • Function : Author
Fulya Eylem Yediay
  • Function : Author
Igor Gutiérrez-Zugasti
  • Function : Author
Ilya Merts
Inna Potekhina
  • Function : Author
Irina Shevnina
  • Function : Author
Isin Altinkaya
Jean Guilaine
  • Function : Author
Jesper Hansen
  • Function : Author
Joan Emili Aura Tortosa
  • Function : Author
João Zilhão
Jorge Vega
  • Function : Author
Kristoffer Buck Pedersen
Krzysztof Tunia
  • Function : Author
Lei Zhao
Liudmila Mylnikova
  • Function : Author
Lars Larsson
  • Function : Author
Levon Yepiskoposyan
  • Function : Author
Lisbeth Pedersen
  • Function : Author
Lucia Sarti
  • Function : Author
Lutz Klassen
  • Function : Author
Malou Blank
Manuel González-Morales
Mara Silvestrini
  • Function : Author
Maria Vretemark
  • Function : Author
Marina Nesterova
  • Function : Author
Marina Rykun
  • Function : Author
Mario Federico Rolfo
  • Function : Author
Marzena Szmyt
  • Function : Author
Marcin Przybyła
  • Function : Author
Mauro Calattini
  • Function : Author
Mikhail Sablin
Miluše Dobisíková
  • Function : Author
Morten Meldgaard
  • Function : Author
Morten Johansen
  • Function : Author
Natalia Berezina
Nick Card
  • Function : Author
Nikolai Saveliev
  • Function : Author
Olga Poshekhonova
  • Function : Author
Olga Rickards
  • Function : Author
Olga Lozovskaya
Olivér Gábor
  • Function : Author
Otto Christian Uldum
  • Function : Author
Paola Aurino
  • Function : Author
Pavel Kosintsev
  • Function : Author
Patrice Courtaud
  • Function : Author
Patricia Ríos
  • Function : Author
Peder Mortensen
  • Function : Author
Per Lotz
  • Function : Author
Per Persson
Pernille Bangsgaard
Peter de Barros Damgaard
  • Function : Author
Peter Vang Petersen
  • Function : Author
Pilar Prieto Martinez
Piotr Włodarczak
Roman Smolyaninov
  • Function : Author
Rikke Maring
  • Function : Author
Roberto Menduiña
  • Function : Author
Ruben Badalyan
  • Function : Author
Rune Iversen
Ruslan Turin
  • Function : Author
Sergey Vasilyev
Sidsel Wåhlin
Svetlana Borutskaya
  • Function : Author
Svetlana Skochina
Søren Anker Sørensen
  • Function : Author
Søren Andersen
  • Function : Author
Thomas Jørgensen
  • Function : Author
Yuri Serikov
  • Function : Author
Vyacheslav Molodin
Vaclav Smrcka
  • Function : Author
Victor Merts
  • Function : Author
Vivek Appadurai
Vyacheslav Moiseyev
  • Function : Author
Yvonne Magnusson
Kurt Kjær
Niels Lynnerup
  • Function : Author
Daniel Lawson
Peter Sudmant
Simon Rasmussen
Thorfinn Sand Korneliussen
Richard Durbin
Rasmus Nielsen
Olivier Delaneau
Thomas Werge
Fernando Racimo
Kristian Kristiansen
  • Function : Author

Abstract

Western Eurasia witnessed several large-scale human migrations during the Holocene. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a 'Neolithic steppe' cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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hal-04443827 , version 1 (23-05-2024)

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Morten Allentoft, Martin Sikora, Alba Refoyo-Martínez, Evan Irving-Pease, Anders Fischer, et al.. Population genomics of post-glacial western Eurasia. Nature, 2024, 625 (7994), pp.301-311. ⟨10.1038/s41586-023-06865-0⟩. ⟨hal-04443827⟩
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