Metabolomics as a tool to elucidate biochemical cold adaptation in insects
Résumé
Metabolomics is an incredibly valuable tool in helping understand insect responses to cold. It not only characterizes how low temperature disrupts metabolic homeostasis, but also how it triggers fundamental adaptive responses, e.g. homeoviscous adaptation and cryoprotectant accumulation. This review outlines the advantages and disadvantages of different metabolomic technologies (NMR- vs. MS-based) and screening approaches (targeted vs. untargeted). We emphasize the importance of time series and tissue-specific data, as well as the challenges of disentangling insect vs. microbiome responses. In addition, we set out the need to move beyond simple correlations between metabolite abundance and tolerance phenotypes by undertaking functional assessments, e.g. using dietary supplementation or injections. We highlight studies at the vanguard of employing these approaches, and where key knowledge gaps remain.
Domaines
Biodiversité et Ecologie
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Hayward et Colinet - 2023 - Metabolomics as a tool to elucidate biochemical co.pdf (1.01 Mo)
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Origine | Fichiers produits par l'(les) auteur(s) |
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Commentaire | No data were used for the research described in the article. |