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Article Dans Une Revue Journal of Proteome Research Année : 2023

The 2022 Report on the Human Proteome from the HUPO Human Proteome Project

Nicolle H Packer
Ileana M Cristea
Cecilia Lindskog
Susan T Weintraub
Sandra Orchard
Michael H A Roehrl
  • Fonction : Auteur
Edouard Nice
Siqi Liu
Nuno Bandeira
Yu-Ju Chen
Tiannan Guo
Ruedi Aebersold
  • Fonction : Auteur
Robert L Moritz
Eric W Deutsch

Résumé

The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) illustrates that protein expression has now been credibly detected (neXtProt PE1 level) for 18,407 (93.2%) of the 19,750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from datasets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, "A Function for Each Protein".
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Dates et versions

hal-04098934 , version 1 (16-05-2023)

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Gilbert S Omenn, Lydie Lane, Christopher M Overall, Charles Pineau, Nicolle H Packer, et al.. The 2022 Report on the Human Proteome from the HUPO Human Proteome Project. Journal of Proteome Research, 2023, 22 (4), pp.1024 - 1042. ⟨10.1021/acs.jproteome.2c00498⟩. ⟨hal-04098934⟩
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