ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Environment International Année : 2023

ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors

Résumé

Growing evidence shows that endocrine disruptors (EDs), known to affect the reproductive system, may also disturb other hormone-regulated functions leading to cancers, neurodevelopmental defects, metabolic and immune diseases. To reduce exposure to EDs and limit their health effects, development of screening and mechanism-based assays to identify EDs is encouraged. Nevertheless, the crucial validation step of test methods by regulatory bodies is a time- and resource-consuming process. One of the main raisons of this long duration process is that method developers, mainly researchers, are not fully aware of the regulatory needs to validate a test. We propose an online self-assessment questionnaire (SAQ) called ReadEDTest easy to be used by all researchers. The aim of ReadEDTest is to speed up the validation process by assessing readiness criteria of in vitro and fish embryo ED test methods under development. The SAQ is divided into 7 sections and 13 sub-sections containing essential information requested by the validating bodies. The readiness of the tests can be assessed by specific score limits for each sub-section. Results are displayed via a graphical representation to help identification of the sub-sections having sufficient or insufficient information. The relevance of the proposed innovative tool was supported using two test methods already validated by the OECD and four under development test methods.
Fichier principal
Vignette du fichier
hal-04094681.pdf (3.4 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04094681 , version 1 (31-05-2023)

Identifiants

Citer

Thibault Crouzet, Elise Grignard, François Brion, Etienne B Blanc, Normand Podechard, et al.. ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors. Environment International, 2023, 174, pp.107910. ⟨10.1016/j.envint.2023.107910⟩. ⟨hal-04094681⟩
39 Consultations
32 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More