Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
Danyel Lee
(1, 2)
,
Jérémie Le Pen
,
Ahmad Yatim
(3)
,
Beihua Dong
,
Yann Aquino
(4)
,
Masato Ogishi
(1)
,
Rémi Pescarmona
(5, 6, 7, 8)
,
Estelle Talouarn
(9)
,
Darawan Rinchai
(10)
,
Peng Zhang
(1, 2)
,
Magali Perret
(11)
,
Zhiyong Liu
(12)
,
Iolanda Jordan
(13)
,
Sefika Elmas Bozdemir
,
Gulsum Iclal Bayhan
,
Camille Beaufils
,
Lucy Bizien
(2, 14, 15)
,
Aurelie Bisiaux
(16)
,
Weite Lei
,
Milena Hasan
(17)
,
Jie Chen
(1, 18)
,
Christina Gaughan
,
Abhishek Asthana
(19)
,
Valentina Libri
(20)
,
Joseph Luna
,
Fabrice Jaffré
,
H.-Heinrich Hoffmann
,
Eleftherios Michailidis
,
Marion Moreews
(5)
,
Yoann Seeleuthner
,
Kaya Bilguvar
,
Shrikant Mane
,
Carlos Flores
,
Yu Zhang
,
Andrés Arias
,
Rasheed Bailey
,
Agatha Schlüter
,
Baptiste Milisavljevic
,
Benedetta Bigio
,
Tom Le Voyer
,
Marie Materna
,
Adrian Gervais
,
Marcela Moncada-Velez
,
Francesca Pala
,
Tomi Lazarov
,
Romain Levy
,
Anna-Lena Neehus
,
Jérémie Rosain
,
Jessica Peel
,
Yi-Hao Chan
,
Marie-Paule Morin
,
Rosa Maria Pino-Ramirez
,
Serkan Belkaya
,
Lazaro Lorenzo
,
Jordi Anton
,
Selket Delafontaine
,
Julie Toubiana
(21)
,
Fanny Bajolle
,
Victoria Fumadó
,
Marta Dediego
,
Nadhira Fidouh
,
Flore Rozenberg
,
Jordi Pérez-Tur
,
Shuibing Chen
,
Todd Evans
,
Frédéric Geissmann
,
Pierre Lebon
,
Susan Weiss
,
Damien Bonnet
,
Xavier Duval
(22)
,
Qiang Pan-Hammarström
,
Anna Planas
,
Isabelle Meyts
,
Filomeen Haerynck
,
Aurora Pujol
,
Vanessa Sancho-Shimizu
,
Clifford Dalgard
,
Jacinta Bustamante
,
Anne Puel
,
Stéphanie Boisson-Dupuis
,
Bertrand Boisson
,
Tom Maniatis
,
Qian Zhang
,
Paul Bastard
,
Luigi Notarangelo
,
Vivien Béziat
,
Rebeca Perez de Diego
,
Carlos Rodriguez-Gallego
,
Helen Su
,
Richard Lifton
,
Emmanuelle Jouanguy
,
Aurélie Cobat
,
Laia Alsina
,
Sevgi Keles
,
Elie Haddad
,
Laurent Abel
,
Alexandre Belot
(7)
,
Lluis Quintana-Murci
(16)
,
Charles Rice
,
Robert Silverman
,
Shen-Ying Zhang
,
Jean-Laurent Casanova
,
Loubna Alavoine
(23)
,
Sylvie Behillil
,
Charles Burdet
,
Charlotte Charpentier
,
Aline Dechanet
,
Diane Descamps
,
Xavier Duval
,
Jean-Luc Ecobichon
,
Vincent Enouf
,
Wahiba Frezouls
,
Nadhira Houhou
,
Ouifiya Kafif
,
Jonathan Lehacaut
,
Sophie Letrou
,
Bruno Lina
(5)
,
Jean-Christophe Lucet
,
Pauline Manchon
,
Mariama Nouroudine
,
Valentine Piquard
,
Caroline Quintin
,
Michael Thy
,
Sarah Tubiana
(24)
,
Sylvie van der Werf
,
Valérie Vignali
,
Benoit Visseaux
,
Yazdan Yazdanpanah
,
Abir Chahine
,
Nawal Waucquier
,
Maria-Claire Migaud
(25)
,
Dominique Deplanque
,
Félix Djossou
,
Mayka Mergeay-Fabre
(26)
,
Aude Lucarelli
,
Magalie Demar
,
Léa Bruneau
,
Patrick Gérardin
,
Adrien Maillot
(27)
,
Christine Payet
,
Bruno Laviolle
(28, 29)
,
Fabrice Laine
(28, 29)
,
Christophe Paris
(28, 29)
,
Mireille Desille-Dugast
(28, 29)
,
Julie Fouchard
(28, 29)
,
Denis Malvy
,
Duc Nguyen
,
Thierry Pistone
,
Pauline Perreau
,
Valérie Gissot
,
Carole Le Goas
,
Samatha Montagne
,
Lucie Richard
,
Catherine Chirouze
,
Kévin Bouiller
,
Maxime Desmarets
,
Alexandre Meunier
,
Benjamin Lefèvre
,
Hélène Jeulin
,
Karine Legrand
,
Sandra Lomazzi
,
Bernard Tardy
,
Amandine Gagneux-Brunon
,
Frédérique Bertholon
,
Elisabeth Botelho-Nevers
,
Kouakam Christelle
,
Leturque Nicolas
,
Layidé Roufai
,
Karine Amat
,
Sandrine Couffin-Cadiergues
,
Hélène Espérou
,
Samia Hendou
,
Laurent Abel
,
Hassan Abolhassani
,
Sergio Aguilera-Albesa
,
Alessandro Aiuti
,
Ozge Metin Akcan
,
Nihal Akcay
,
Gulsum Alkan
,
Suzan Alkhater
,
Luis Miguel Allende
,
Yosunkaya Alper
,
Naima Amenzoui
,
Mark Anderson
,
Lisa Arkin
,
Melodie Aubart
,
Iryna Avramenko
,
Şehnaz Aydemir
,
Zeynep Gökçe Gayretli Aydin
,
Caner Aytekin
,
Gökhan Aytekin
,
Selma Erol Aytekin
,
Silvia Yumi Bando
,
Kathie Beland
,
Serkan Belkaya
,
Catherine Biggs
,
Agurtzane Bilbao Aburto
,
Geraldine Blanchard-Rohner
,
Daniel Blázquez-Gamero
,
Marketa Bloomfield
,
Dusan Bogunovic
,
Anastasia Bondarenko
,
Alessandro Borghesi
,
Amed Aziz Bousfiha
,
Oksana Boyarchuk
,
Petter Brodin
,
Yenan Bryceson
,
Giorgia Bucciol
,
Valeria Calcaterra
,
Giorgio Casari
,
Andre Cavalcanti
,
Jale Bengi Celik
,
George Chrousos
,
Roger Colobran
,
Antonio Condino-Neto
,
Francesca Conti
,
Megan Cooper
,
Taner Coskuner
,
Cyril Cyrus
,
Enza D’auria
,
Selket Delafontaine
,
Beth Drolet
,
Burcu Bursal Duramaz
,
Loubna El Zein
,
Marwa Elnagdy
,
Melike Emiroglu
,
Emine Hafize Erdeniz
,
Marianna Fabi
,
Hagit Baris Feldman
,
Jacques Fellay
,
Filip Fencl
,
Filippos Filippatos
,
Julie Freiss
,
Jiri Fremuth
,
Alenka Gagro
,
Blanca Garcia-Solis
,
Gianluca Vergine
,
Rafaela González-Montelongo
,
Yahya Gul
,
Belgin Gülhan
,
Sara Sebnem Kilic Gultekin
,
Marta Gut
,
Rabih Halwani
,
Lennart Hammarström
,
Nevin Hatipoğlu
,
James Heath
,
Sarah Henrickson
,
Elisa Hernandez-Brito
,
Ilse Hoffman
,
Levi Hoste
,
Elena Hsieh
,
Antonio Íñigo-Campos
,
Yuval Itan
,
Petr Jabandziev
,
Bahar Kandemir
,
Saliha Kanık-Yüksek
,
Hasan Kapakli
,
Adem Karbuz
,
Ozgur Kasapcopur
,
Robin Kechiche
,
Yasemin Kendir Demirkol
,
Omer Kilic
,
Stella Kim Hansen
,
Adam Klocperk
,
Yu-Lung Lau
,
Jan Lebl
,
José Lorenzo-Salazar
,
Carrie Lucas
,
Majistor Maglorius
,
Laura Marque
,
Yeray Novoa Medina
,
Abián Montesdeoca Melián
,
Alexios-Fotios Mentis
,
Michele Pato
,
Athanasios Michos
,
Joshua Milner
,
Trine Mogensen
,
Adrián Muñoz-Barrera
,
Serdar Nepesov
,
João Farela Neves
,
Ashley Ng
,
Lisa Ng
,
Antonio Novelli
,
Giuseppe Novelli
,
Fatma Nur Oz
,
J. Gonzalo Ocejo-Viñals
,
Satoshi Okada
,
Zerrin Orbak
,
Ahmet Osman Kilic
,
Hind Ouair
,
Şadiye Kübra Tüter Öz
,
Tayfun Özçelik
,
Esra Akyüz Özkan
,
Aslınur Özkaya Parlakay
,
Carlos Pato
,
Estela Paz-Artal
,
Simon Pelham
,
Isabelle Pellier
,
Quentin Philippot
,
Laura Planas-Serra
,
Samira Plassart
,
Petra Pokorna
,
Meltem Polat
,
Cecilia Poli
,
Carolina Prando
,
Laurent Renia
,
Jacques Rivière
,
Agustí Rodríguez-Palmero
,
Lucie Roussel
,
Luis Rubio-Rodriguez
,
Moro Salifu
,
Lumir Sasek
,
Laura Sasia
,
Anna Scherbina
,
Erica Schmitt
,
Anna Sediva
,
Esra Sevketoglu
,
Katerina Slaba
,
Ondrej Slaby
,
Ali Sobh
,
Jordi Solé-Violán
,
Pere Soler-Palacin
,
Lien de Somer
,
Betül Sözeri
,
András Spaan
,
Yuriy Stepanovskiy
,
Stuart Tangye
,
Gonul Tanir
,
Elizabeth Barbara Tatsi
,
Christian Thorball
,
Selda Hancerli Torun
,
Stuart Turvey
,
Mohammed Uddin
,
Emel Uyar
,
Juan Valencia-Ramos
,
Ana Maria van den Rym
,
Hulya Vatansev
,
Martín Castillo de Vera
,
François Vermeulen
,
Donald Vinh
,
Alla Volokha
,
Horst von Bernuth
,
Carine Wouters
,
Aysun Yahşi
,
Volkan Yarar
,
Osman Yesilbas
,
Mehmet Yıldız
,
Mayana Zatz
,
Pawel Zawadzki
,
Gianvincenzo Zuccotti
,
Shen-Ying Zhang
,
Jean-Laurent Casanova
1
Rockefeller University [New York]
2 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
3 IGH - Institut de génétique humaine
4 GEMS - Génomique évolutive, modélisation et santé
5 CIRI - Centre International de Recherche en Infectiologie
6 RAISE - Centre de référence des rhumatismes inflammatoires et maladies auto-immunes systémiques rares de l’enfant / National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children [Lyon]
7 HCL - Hospices Civils de Lyon
8 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
9 GenPhySE - Génétique Physiologie et Systèmes d'Elevage
10 Sidra Medicine [Doha, Qatar]
11 BIOASTER Technology Research Institute, Lyon, France
12 St. Giles Laboratory of Human Genetics of Infectious Diseases
13 Department of Paediatrics and Intensive Care
14 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition
15 Département de Pédiatrie et maladies infectieuses [CHU Necker]
16 Génétique Evolutive Humaine - Human Evolutionary Genetics
17 CRT - Centre de Recherche Translationnelle - Center for Translational Science
18 Shangaï Jiao Tong University [Shangaï]
19 Sheffield Hallam University
20 IP - Institut Pasteur [Paris]
21 CHU Necker - Enfants Malades [AP-HP]
22 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
23 CIC 1425 - Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique
24 Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens
25 CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301
26 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
27 CIC 1410 - Centre d'Investigation Clinique de La Réunion - INSERM
28 CIC - Centre d'Investigation Clinique [Rennes]
29 CHU Pontchaillou [Rennes]
2 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
3 IGH - Institut de génétique humaine
4 GEMS - Génomique évolutive, modélisation et santé
5 CIRI - Centre International de Recherche en Infectiologie
6 RAISE - Centre de référence des rhumatismes inflammatoires et maladies auto-immunes systémiques rares de l’enfant / National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children [Lyon]
7 HCL - Hospices Civils de Lyon
8 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
9 GenPhySE - Génétique Physiologie et Systèmes d'Elevage
10 Sidra Medicine [Doha, Qatar]
11 BIOASTER Technology Research Institute, Lyon, France
12 St. Giles Laboratory of Human Genetics of Infectious Diseases
13 Department of Paediatrics and Intensive Care
14 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition
15 Département de Pédiatrie et maladies infectieuses [CHU Necker]
16 Génétique Evolutive Humaine - Human Evolutionary Genetics
17 CRT - Centre de Recherche Translationnelle - Center for Translational Science
18 Shangaï Jiao Tong University [Shangaï]
19 Sheffield Hallam University
20 IP - Institut Pasteur [Paris]
21 CHU Necker - Enfants Malades [AP-HP]
22 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
23 CIC 1425 - Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique
24 Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens
25 CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301
26 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
27 CIC 1410 - Centre d'Investigation Clinique de La Réunion - INSERM
28 CIC - Centre d'Investigation Clinique [Rennes]
29 CHU Pontchaillou [Rennes]
Danyel Lee
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Jérémie Le Pen
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Beihua Dong
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Yann Aquino
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Masato Ogishi
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Rémi Pescarmona
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Estelle Talouarn
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Darawan Rinchai
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Peng Zhang
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Magali Perret
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Iolanda Jordan
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Sefika Elmas Bozdemir
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Weite Lei
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Carlos Flores
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Andrés Arias
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Rasheed Bailey
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Agatha Schlüter
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Baptiste Milisavljevic
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Benedetta Bigio
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Marie Materna
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Francesca Pala
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Tomi Lazarov
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Romain Levy
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Anna-Lena Neehus
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Jérémie Rosain
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Jessica Peel
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Yi-Hao Chan
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Marie-Paule Morin
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Rosa Maria Pino-Ramirez
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Serkan Belkaya
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Victoria Fumadó
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Damien Bonnet
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Qiang Pan-Hammarström
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Anna Planas
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Filomeen Haerynck
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Aurora Pujol
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Vanessa Sancho-Shimizu
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Clifford Dalgard
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Anne Puel
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Bertrand Boisson
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Tom Maniatis
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Qian Zhang
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Paul Bastard
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Luigi Notarangelo
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Carlos Rodriguez-Gallego
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Richard Lifton
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Aurélie Cobat
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Laia Alsina
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Sevgi Keles
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Elie Haddad
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Laurent Abel
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Alexandre Belot
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Lluis Quintana-Murci
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Charles Rice
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Robert Silverman
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Shen-Ying Zhang
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Jean-Laurent Casanova
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Sylvie Behillil
- Function : Author
Charles Burdet
- Function : Author
Charlotte Charpentier
- Function : Author
Aline Dechanet
- Function : Author
Diane Descamps
- Function : Author
Xavier Duval
- Function : Author
Jean-Luc Ecobichon
- Function : Author
Vincent Enouf
- Function : Author
Wahiba Frezouls
- Function : Author
Nadhira Houhou
- Function : Author
Ouifiya Kafif
- Function : Author
Jonathan Lehacaut
- Function : Author
Sophie Letrou
- Function : Author
Jean-Christophe Lucet
- Function : Author
Pauline Manchon
- Function : Author
Mariama Nouroudine
- Function : Author
Valentine Piquard
- Function : Author
Caroline Quintin
- Function : Author
Michael Thy
- Function : Author
Sylvie van der Werf
- Function : Author
- PersonId : 1202918
- IdHAL : sylvie-van-der-werf
Valérie Vignali
- Function : Author
Benoit Visseaux
- Function : Author
Yazdan Yazdanpanah
- Function : Author
Abir Chahine
- Function : Author
Nawal Waucquier
- Function : Author
Dominique Deplanque
- Function : Author
Félix Djossou
- Function : Author
Aude Lucarelli
- Function : Author
Magalie Demar
- Function : Author
Léa Bruneau
- Function : Author
Patrick Gérardin
- Function : Author
Christine Payet
- Function : Author
Denis Malvy
- Function : Author
Duc Nguyen
- Function : Author
Thierry Pistone
- Function : Author
Pauline Perreau
- Function : Author
Valérie Gissot
- Function : Author
Carole Le Goas
- Function : Author
Samatha Montagne
- Function : Author
Lucie Richard
- Function : Author
Catherine Chirouze
- Function : Author
Kévin Bouiller
- Function : Author
Maxime Desmarets
- Function : Author
Alexandre Meunier
- Function : Author
Benjamin Lefèvre
- Function : Author
Hélène Jeulin
- Function : Author
- PersonId : 174588
- IdHAL : helene-jeulin
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Karine Legrand
- Function : Author
Sandra Lomazzi
- Function : Author
Bernard Tardy
- Function : Author
Amandine Gagneux-Brunon
- Function : Author
Frédérique Bertholon
- Function : Author
Elisabeth Botelho-Nevers
- Function : Author
Kouakam Christelle
- Function : Author
Leturque Nicolas
- Function : Author
Layidé Roufai
- Function : Author
Karine Amat
- Function : Author
Sandrine Couffin-Cadiergues
- Function : Author
Hélène Espérou
- Function : Author
Samia Hendou
- Function : Author
Laurent Abel
- Function : Author
Hassan Abolhassani
- Function : Author
Sergio Aguilera-Albesa
- Function : Author
Alessandro Aiuti
- Function : Author
Ozge Metin Akcan
- Function : Author
Nihal Akcay
- Function : Author
Gulsum Alkan
- Function : Author
Suzan Alkhater
- Function : Author
Luis Miguel Allende
- Function : Author
Yosunkaya Alper
- Function : Author
Naima Amenzoui
- Function : Author
Mark Anderson
- Function : Author
Lisa Arkin
- Function : Author
Melodie Aubart
- Function : Author
Iryna Avramenko
- Function : Author
Şehnaz Aydemir
- Function : Author
Zeynep Gökçe Gayretli Aydin
- Function : Author
Caner Aytekin
- Function : Author
Gökhan Aytekin
- Function : Author
Selma Erol Aytekin
- Function : Author
Silvia Yumi Bando
- Function : Author
Kathie Beland
- Function : Author
Serkan Belkaya
- Function : Author
Catherine Biggs
- Function : Author
Agurtzane Bilbao Aburto
- Function : Author
Geraldine Blanchard-Rohner
- Function : Author
Daniel Blázquez-Gamero
- Function : Author
Marketa Bloomfield
- Function : Author
Dusan Bogunovic
- Function : Author
Anastasia Bondarenko
- Function : Author
Alessandro Borghesi
- Function : Author
Amed Aziz Bousfiha
- Function : Author
Oksana Boyarchuk
- Function : Author
Petter Brodin
- Function : Author
Yenan Bryceson
- Function : Author
Giorgia Bucciol
- Function : Author
Valeria Calcaterra
- Function : Author
Giorgio Casari
- Function : Author
Andre Cavalcanti
- Function : Author
Jale Bengi Celik
- Function : Author
George Chrousos
- Function : Author
Roger Colobran
- Function : Author
Antonio Condino-Neto
- Function : Author
Francesca Conti
- Function : Author
Megan Cooper
- Function : Author
Taner Coskuner
- Function : Author
Cyril Cyrus
- Function : Author
Enza D’auria
- Function : Author
Selket Delafontaine
- Function : Author
Beth Drolet
- Function : Author
Burcu Bursal Duramaz
- Function : Author
Loubna El Zein
- Function : Author
Marwa Elnagdy
- Function : Author
Melike Emiroglu
- Function : Author
Emine Hafize Erdeniz
- Function : Author
Marianna Fabi
- Function : Author
Hagit Baris Feldman
- Function : Author
Jacques Fellay
- Function : Author
Filip Fencl
- Function : Author
Filippos Filippatos
- Function : Author
Julie Freiss
- Function : Author
Jiri Fremuth
- Function : Author
Alenka Gagro
- Function : Author
Blanca Garcia-Solis
- Function : Author
Gianluca Vergine
- Function : Author
Rafaela González-Montelongo
- Function : Author
Yahya Gul
- Function : Author
Belgin Gülhan
- Function : Author
Sara Sebnem Kilic Gultekin
- Function : Author
Marta Gut
- Function : Author
Rabih Halwani
- Function : Author
Lennart Hammarström
- Function : Author
Nevin Hatipoğlu
- Function : Author
James Heath
- Function : Author
Sarah Henrickson
- Function : Author
Elisa Hernandez-Brito
- Function : Author
Ilse Hoffman
- Function : Author
Levi Hoste
- Function : Author
Elena Hsieh
- Function : Author
Antonio Íñigo-Campos
- Function : Author
Yuval Itan
- Function : Author
Petr Jabandziev
- Function : Author
Bahar Kandemir
- Function : Author
Saliha Kanık-Yüksek
- Function : Author
Hasan Kapakli
- Function : Author
Adem Karbuz
- Function : Author
Ozgur Kasapcopur
- Function : Author
Robin Kechiche
- Function : Author
Yasemin Kendir Demirkol
- Function : Author
Omer Kilic
- Function : Author
Stella Kim Hansen
- Function : Author
Adam Klocperk
- Function : Author
Yu-Lung Lau
- Function : Author
Jan Lebl
- Function : Author
José Lorenzo-Salazar
- Function : Author
Carrie Lucas
- Function : Author
Majistor Maglorius
- Function : Author
Laura Marque
- Function : Author
Yeray Novoa Medina
- Function : Author
Abián Montesdeoca Melián
- Function : Author
Alexios-Fotios Mentis
- Function : Author
Michele Pato
- Function : Author
Athanasios Michos
- Function : Author
Joshua Milner
- Function : Author
Trine Mogensen
- Function : Author
Adrián Muñoz-Barrera
- Function : Author
Serdar Nepesov
- Function : Author
João Farela Neves
- Function : Author
Ashley Ng
- Function : Author
Lisa Ng
- Function : Author
Antonio Novelli
- Function : Author
Giuseppe Novelli
- Function : Author
Fatma Nur Oz
- Function : Author
J. Gonzalo Ocejo-Viñals
- Function : Author
Satoshi Okada
- Function : Author
Zerrin Orbak
- Function : Author
Ahmet Osman Kilic
- Function : Author
Hind Ouair
- Function : Author
Şadiye Kübra Tüter Öz
- Function : Author
Tayfun Özçelik
- Function : Author
Esra Akyüz Özkan
- Function : Author
Aslınur Özkaya Parlakay
- Function : Author
Carlos Pato
- Function : Author
Estela Paz-Artal
- Function : Author
Simon Pelham
- Function : Author
Isabelle Pellier
- Function : Author
Quentin Philippot
- Function : Author
Laura Planas-Serra
- Function : Author
Samira Plassart
- Function : Author
Petra Pokorna
- Function : Author
Meltem Polat
- Function : Author
Cecilia Poli
- Function : Author
Carolina Prando
- Function : Author
Laurent Renia
- Function : Author
Jacques Rivière
- Function : Author
Agustí Rodríguez-Palmero
- Function : Author
Lucie Roussel
- Function : Author
Luis Rubio-Rodriguez
- Function : Author
Moro Salifu
- Function : Author
Lumir Sasek
- Function : Author
Laura Sasia
- Function : Author
Anna Scherbina
- Function : Author
Erica Schmitt
- Function : Author
Anna Sediva
- Function : Author
Esra Sevketoglu
- Function : Author
Katerina Slaba
- Function : Author
Ondrej Slaby
- Function : Author
Ali Sobh
- Function : Author
Jordi Solé-Violán
- Function : Author
Pere Soler-Palacin
- Function : Author
Lien de Somer
- Function : Author
Betül Sözeri
- Function : Author
András Spaan
- Function : Author
Yuriy Stepanovskiy
- Function : Author
Stuart Tangye
- Function : Author
Gonul Tanir
- Function : Author
Elizabeth Barbara Tatsi
- Function : Author
Christian Thorball
- Function : Author
Selda Hancerli Torun
- Function : Author
Stuart Turvey
- Function : Author
Mohammed Uddin
- Function : Author
Emel Uyar
- Function : Author
Juan Valencia-Ramos
- Function : Author
Ana Maria van den Rym
- Function : Author
Hulya Vatansev
- Function : Author
Martín Castillo de Vera
- Function : Author
François Vermeulen
- Function : Author
Donald Vinh
- Function : Author
Alla Volokha
- Function : Author
Horst von Bernuth
- Function : Author
Carine Wouters
- Function : Author
Aysun Yahşi
- Function : Author
Volkan Yarar
- Function : Author
Osman Yesilbas
- Function : Author
Mehmet Yıldız
- Function : Author
Mayana Zatz
- Function : Author
Pawel Zawadzki
- Function : Author
Gianvincenzo Zuccotti
- Function : Author
Shen-Ying Zhang
- Function : Author
Jean-Laurent Casanova
- Function : Author
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 , or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing OAS1 and OAS2 generate 2′-5′-linked oligoadenylates (2-5A) that activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L–deficient cells. Cytokine production in RNase L–deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS–RNase L deficiencies in these patients unleash the production of SARS-CoV-2–triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C.
Domains
Life Sciences [q-bio]
Origin : Publication funded by an institution