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Article Dans Une Revue Magnetic Resonance Materials in Physics, Biology and Medicine Année : 2023

Multi T1-weighted contrast imaging and T1 mapping with compressed sensing FLAWS at 3 T

Résumé

Objective The Fluid And White matter Suppression (FLAWS) MRI sequence provides multiple T1-weighted contrasts of the brain in a single acquisition. However, the FLAWS acquisition time is approximately 8 min with a standard GRAPPA 3 acceleration factor at 3 T. This study aims at reducing the FLAWS acquisition time by providing a new sequence optimization based on a Cartesian phyllotaxis k-space undersampling and a compressed sensing (CS) reconstruction. This study also aims at showing that T1 mapping can be performed with FLAWS at 3 T.Materials and methods The CS FLAWS parameters were determined using a method based on a profit function maximization under constraints. The FLAWS optimization and T1 mapping were assessed with in-silico, in-vitro and in-vivo (10 healthy volunteers) experiments conducted at 3 T.Results In-silico, in-vitro and in-vivo experiments showed that the proposed CS FLAWS optimization allows the acquisition time of a 1 mm-isotropic full-brain scan to be reduced from 8mins to 6mins without decreasing image quality. In addition, these experiments demonstrate that T1 mapping can be performed with FLAWS at 3 T.Discussion The results obtained in this study suggest that the recent advances in FLAWS imaging allow to perform multiple T1-weighted contrast imaging and T1 mapping in a single 6mins sequence acquisition.

Dates et versions

hal-04055913 , version 1 (03-04-2023)

Identifiants

Citer

Jeremy Beaumont, Jurgen Fripp, Parnesh Raniga, Oscar Acosta, Jean-Christophe Ferré, et al.. Multi T1-weighted contrast imaging and T1 mapping with compressed sensing FLAWS at 3 T. Magnetic Resonance Materials in Physics, Biology and Medicine, 2023, pp.1-44. ⟨10.1007/s10334-023-01071-5⟩. ⟨hal-04055913⟩
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