One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Frontiers in Cardiovascular Medicine Année : 2023

One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry

1 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
2 UPS/Inserm U1297 - I2MC - Institut des Maladies Métaboliques et Casdiovasculaires
3 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
6 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
7 Hôpital Nord [CHU - APHM]
8 MARS cardio - Mediterranean Association for Research and Studies in Cardiology
9 AMU - Aix Marseille Université
10 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
11 LTSI - Laboratoire Traitement du Signal et de l'Image
12 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
13 CHU Henri Mondor [Créteil]
14 IMRB - Institut Mondor de Recherche Biomédicale
15 Hôpital de Hautepierre [Strasbourg]
16 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
17 Hôpital Cochin [AP-HP]
18 UPCité - Université Paris Cité
19 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
20 TIMONE - Hôpital de la Timone [CHU - APHM]
21 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
22 Hôpital de la Croix-Rousse [CHU - HCL]
23 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
24 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
25 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
26 CH de Saint-Malo [Broussais]
27 HUS - Les Hôpitaux Universitaires de Strasbourg
28 Nouvel Hôpital Civil de Strasbourg
29 CHU Clermont-Ferrand
30 UCA - Université Clermont Auvergne
31 CHU Lyon - Centre Hospitalier Universitaire de Lyon
32 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
33 UM - Université de Montpellier
34 Hôpital Lariboisière-Fernand-Widal [APHP]
35 Hôpital Haut-Lévêque [CHU Bordeaux]
36 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
37 Hôpital Xavier Arnozan
38 HEGP - Hôpital Européen Georges Pompidou [APHP]
39 UPD5 - Université Paris Descartes - Paris 5
Sebastien Champion
  • Fonction : Auteur

Résumé

Background Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers remains unclear. The aim of this study was to evaluate 1-year outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS. Methods FRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population. Results Within 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02). Conclusion VA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation. Clinical trial registration https://clinicaltrials.gov , identifier NCT02703038.
Fichier principal
Vignette du fichier
2023 Cherbi et al., One.pdf (1.24 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03994128 , version 1 (17-02-2023)

Identifiants

Citer

Miloud Cherbi, François Roubille, Nicolas Lamblin, Laurent Bonello, Guillaume Leurent, et al.. One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry. Frontiers in Cardiovascular Medicine, 2023, 10, ⟨10.3389/fcvm.2023.1092904⟩. ⟨hal-03994128⟩
31 Consultations
19 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More