Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review - Université de Rennes Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review

Résumé

The real impact of nanoparticles on male fertility is evaluated after a careful analysis of the available literature. The first part reviews animal models to understand the testicular biodistribution and biopersistence of nanoparticles, while the second part evaluates their in vitro and in vivo biotoxicity. Our main findings suggest that nanoparticles are generally able to reach the testicle in small quantities where they persist for several months, regardless of the route of exposure. However, there is not enough evidence that they can cross the blood-testis barrier. Of note, the majority of nanoparticles have low direct toxicity to the testis, but there are indications that some might act as endocrine disruptors. Overall, the impact on spermatogenesis in adults is generally weak and reversible, but exceptions exist and merit increased attention. Finally, we comment on several methodological or analytical biases which have led some studies to exaggerate the reprotoxicity of nanoparticles. In the future, rigorous clinical studies in tandem with mechanistic studies are needed to elucidate the real risk posed by nanoparticles on male fertility.
Fichier principal
Vignette du fichier
ijms-24-00576.pdf (2.12 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03967605 , version 1 (30-05-2023)

Identifiants

Citer

Jean-Philippe Klein, Lionel Mery, Delphine Boudard, Célia Ravel, Michèle Cottier, et al.. Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review. International Journal of Molecular Sciences, 2023, 24 (1), ⟨10.3390/ijms24010576⟩. ⟨hal-03967605⟩
48 Consultations
37 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More