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                <title level="j">The Journal of Pediatrics</title>
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                  <date type="datePub">2023-02</date>
                  <date type="dateEpub">2022-09-28</date>
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              <classCode scheme="mesh">Cytomegalovirus / genetics</classCode>
              <classCode scheme="mesh">Cytomegalovirus Infections* / complications</classCode>
              <classCode scheme="mesh">DNA, Viral / analysis</classCode>
              <classCode scheme="mesh">Infant, Newborn, Diseases*</classCode>
              <classCode scheme="mesh">Pregnancy</classCode>
              <classCode scheme="mesh">Real-Time Polymerase Chain Reaction</classCode>
              <classCode scheme="mesh">Saliva / chemistry</classCode>
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              <p>Objective: To evaluate cytomegalovirus (CMV) viral load dynamics in blood and saliva during the first two years of life in symptomatic and asymptomatic infected infants and to identify whether these kinetics could have practical clinical implications.Study design: The Cymepedia cohort prospectively included 256 congenitally infected neonates followed for two years. Whole blood and saliva were collected at inclusion, months 4 and 12, and saliva at months 18 and 24. Real-time CMV PCR was performed, results expressed as log10 IU/mL in blood and in copies/mL in saliva.Results: Viral load in saliva progressively decreased from 7.5 log10 at birth to 3.3 log10 at month 24. CMV PCR in saliva was positive in 100% and 96% of infants at 6 and 12 months, respectively. In the first month of life, neonatal saliva viral load &lt;5 log10 was related to a late CMV transplacental passage. Detection in blood was positive in 92% (147/159) of neonates in the first month of life. No viral load threshold values in blood or saliva could be associated with a high risk of sequelae. Neonatal blood viral load &lt;3 log10 IU/ml had a 100% negative predictive value (NPV) for long-term sequelae.Conclusions: Viral loads in blood and saliva by CMV PCR testing in congenital infection fall over the first 24 months. In this study of infants affected mainly after primary maternal infection during pregnancy, all salivary samples were positive in the first 6 months of life and sequelae were not seen in infants with neonatal blood viral load &lt;3 log10 IU/mL.</p>
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              <addrLine>Site de Poissy10 rue du Champ Gaillard - PoissySite de Saint-Germain-en-Laye20 rue Armagis - Saint-Germain-en-Laye</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-417872" status="VALID">
          <idno type="ISNI">0000 0004 0638 9491 </idno>
          <idno type="ROR">https://ror.org/00s7v8q53</idno>
          <orgName>Hôpital de la Conception [CHU - APHM]</orgName>
          <orgName type="acronym">LA CONCEPTION</orgName>
          <date type="start">1985-01-01</date>
          <desc>
            <address>
              <addrLine>147 Boulevard Baille 13005 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-conception</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-262116" status="INCOMING">
          <orgName>Service de Réanimation Néonatale</orgName>
          <orgName type="acronym">NICE - Réa Néonat</orgName>
          <desc>
            <address>
              <addrLine>Service de réanimation néonatale, hôpital Archet-II, CHU de Nice, Nice, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300113" type="direct"/>
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        </org>
        <org type="laboratory" xml:id="struct-1153016" status="VALID">
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          <desc>
            <address>
              <addrLine>Hôpital des enfants, 330, avenue de Grande Bretagne - TSA 70034 - 31059 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr/-pediatrie-neonatologie-</ref>
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        <org type="laboratory" xml:id="struct-83348" status="VALID">
          <orgName>Service de Pédiatrie Néonatale et Réanimation – Neuropédiatrie [CHU Rouen]</orgName>
          <desc>
            <address>
              <addrLine>1 rue de Germont 76031 Rouen cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rouen.fr/service/pediatrie-neonatale-reanimation/</ref>
          </desc>
          <listRelation>
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        <org type="institution" xml:id="struct-301315" status="VALID">
          <idno type="ISNI">0000 0001 0304 0719 </idno>
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          <orgName>Hôpital Nord [CHU - APHM]</orgName>
          <date type="start">1964</date>
          <desc>
            <address>
              <addrLine>Hôpital Nord - Chemin des Bourrely13915Marseille cedex 20</addrLine>
              <country key="FR"/>
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            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-nord</ref>
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        </org>
        <org type="institution" xml:id="struct-300149" status="VALID">
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            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
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          <listRelation>
            <relation active="#struct-211628" type="direct"/>
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        </org>
        <org type="laboratory" xml:id="struct-519988" status="VALID">
          <orgName>Service de Réanimation pédiatrique et Néonatalogie [CHU Saint Etienne]</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire de Saint-Étienne - 42055 SAINT-ÉTIENNE Cedex 2</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-51335" type="direct"/>
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        </org>
        <org type="regrouplaboratory" xml:id="struct-565406" status="VALID">
          <orgName>Département de Néonatologie [CHU de Rennes]</orgName>
          <desc>
            <address>
              <country key="FR"/>
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          </desc>
          <listRelation>
            <relation active="#struct-301327" type="direct"/>
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        </org>
        <org type="department" xml:id="struct-495459" status="VALID">
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          <desc>
            <address>
              <addrLine>123 Boulevard de Port-Royal, 75014 Paris.</addrLine>
              <country key="FR"/>
            </address>
          </desc>
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            <relation active="#struct-300068" type="direct"/>
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        <org type="laboratory" xml:id="struct-1221820" status="VALID">
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          <desc>
            <address>
              <addrLine>Hôpital Femme-Enfant-HématologieAvenue de la Côte de NacreCS 3000114033 Caen cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-caen.fr/page-services/neonatalogie/</ref>
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          <desc>
            <address>
              <addrLine>Hôpital Morvan, Centre Hospitalo-Universitaire, Brest, France</addrLine>
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            <address>
              <addrLine>149 Rue de Sèvres 75015 Paris</addrLine>
              <country key="FR"/>
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            <ref type="url">https://hopital-necker.aphp.fr/</ref>
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            <address>
              <addrLine>CHU Necker Enfants Malades, 149 Rue de Sèvres, 75015 Paris</addrLine>
              <country key="FR"/>
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            <address>
              <country key="FR"/>
            </address>
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          <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName>
          <orgName type="acronym">UPEC UP12</orgName>
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              <country key="FR"/>
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          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300113" status="VALID">
          <idno type="ROR">https://ror.org/05qsjq305</idno>
          <orgName>Centre Hospitalier Universitaire de Nice</orgName>
          <orgName type="acronym">CHU Nice</orgName>
          <desc>
            <address>
              <addrLine>30, Voie RomaineCS 51069 - 06001 Nice Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nice.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1153000" status="VALID">
          <orgName>Pôle Enfants [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>Toulouse</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
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        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.chu-toulouse.fr</ref>
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        </org>
        <org type="regrouplaboratory" xml:id="struct-300106" status="VALID">
          <idno type="ROR">https://ror.org/00cxy0s05</idno>
          <orgName>Hôpital Charles Nicolle [Rouen]</orgName>
          <desc>
            <address>
              <addrLine>CHU de Rouen1 rue de Germont, 76031 Rouen cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rouen.fr/</ref>
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        <org type="institution" xml:id="struct-300147" status="VALID">
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          <desc>
            <address>
              <addrLine>1 rue de Germont 76031 Rouen cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rouen.fr/</ref>
          </desc>
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          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
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        <org type="institution" xml:id="struct-300318" status="VALID">
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          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
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            <ref type="url">http://www.univ-rouen.fr/</ref>
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          <orgName type="acronym">HUS</orgName>
          <desc>
            <address>
              <addrLine>1 place de l'hôpital BP 426 67091 Strasbourg cedex</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.chru-strasbourg.fr/</ref>
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        </org>
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          <orgName>Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]</orgName>
          <orgName type="acronym">CHU ST-E</orgName>
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          <desc>
            <address>
              <addrLine>42055 Saint Etienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-st-etienne.fr/</ref>
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          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
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          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
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          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
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          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
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            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
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            <address>
              <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
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          <orgName type="acronym">UNICAEN</orgName>
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            <address>
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