Encapsulation of Luminescent Gold Nanoclusters into Synthetic Vesicles - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Nanomaterials Année : 2022

Encapsulation of Luminescent Gold Nanoclusters into Synthetic Vesicles

Résumé

Gold nanoclusters (Au NCs) are attractive luminescent nanoprobes for biomedical applications. In vivo biosensing and bioimaging requires the delivery of the Au NCs into subcellular compartments. In this view, we explore here the possible encapsulation of ultra-small-sized red and blue emitting Au NCs into liposomes of various sizes and chemical compositions. Different methods were investigated to prepare vesicles containing Au NCs in their lumen. The efficiency of the process was correlated to the structural and morphological aspect of the Au NCs' encapsulating vesicles thanks to complementary analyses by SAXS, cryo-TEM, and confocal microscopy techniques. Cell-like-sized vesicles (GUVs) encapsulating red or blue Au NCs were successfully obtained by an innovative method using emulsion phase transfer. Furthermore, exosome-like-sized vesicles (LUVs) containing Au NCs were obtained with an encapsulation yield of 40%, as estimated from ICP-MS.

Domaines

Matériaux Imagerie
Fichier principal
Vignette du fichier
nanomaterials-12-03875.pdf (1.95 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03839780 , version 1 (04-11-2022)

Identifiants

Citer

Regina M Chiechio, Solène Ducarre, Célia Marets, Aurélien Dupont, Pascale Even-Hernandez, et al.. Encapsulation of Luminescent Gold Nanoclusters into Synthetic Vesicles. Nanomaterials, 2022, 12 (21), pp.3875. ⟨10.3390/nano12213875⟩. ⟨hal-03839780⟩
67 Consultations
26 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More