18F-FDG PET/CT-Based Prognostic Survival Model After Surgery for Head and Neck Cancer - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Nuclear Medicine Année : 2022

18F-FDG PET/CT-Based Prognostic Survival Model After Surgery for Head and Neck Cancer

Résumé

The aims of this multicenter study were to identify clinical and preop-erative PET/CT parameters predicting overall survival (OS) and distant metastasis???free survival (DMFS) in a cohort of head and neck squa-mous cell carcinoma patients treated with surgery, to generate a prog-nostic model of OS and DMFS, and to validate this prognostic model with an independent cohort. Methods: A total of 382 consecutive patients with head and neck squamous cell carcinoma, divided into training (n = 318) and validation (n = 64) cohorts, were retrospectively included. The following PET/CT parameters were analyzed: clinical parameters, SUVmax, SUVmean, metabolic tumor volume (MTV), total lesion glycolysis, and distance parameters for the primary tumor and lymph nodes defined by 2 segmentation methods (relative SUVmax threshold and absolute SUV threshold). Cox analyses were performed for OS and DMFS in the training cohort. The concordance index (c-index) was used to identify highly prognostic parameters. These prognostic parameters were externally tested in the validation cohort. Results: In multivariable analysis, the significant parameters for OS were T stage and nodal MTV, with a c-index of 0.64 (P < 0.001). For DMFS, the significant parameters were T stage, nodal MTV, and maxi-mal tumor???node distance, with a c-index of 0.76 (P < 0.001). These combinations of parameters were externally validated, with c-indices of 0.63 (P < 0.001) and 0.71 (P < 0.001) for OS and DMFS, respec-tively. Conclusion: The nodal MTV associated with the maximal tumor???node distance was significantly correlated with the risk of DMFS. Moreover, this parameter, in addition to clinical parameters, was associated with a higher risk of death. These prognostic factors may be used to tailor individualized treatment. <comment>Superscript/Subscript Available</comment

Dates et versions

hal-03826892 , version 1 (24-10-2022)

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Citer

Gwenaelle Creff, Franck Jégoux, Xavier Palard-Novello, Adrien Depeursinge, Ronan Abgral, et al.. 18F-FDG PET/CT-Based Prognostic Survival Model After Surgery for Head and Neck Cancer. Journal of Nuclear Medicine, 2022, 63 (9), pp.1378-1385. ⟨10.2967/jnumed.121.262891⟩. ⟨hal-03826892⟩
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