Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case‐control studies ( SYNERGY ) - Université de Rennes Access content directly
Journal Articles International Journal of Cancer Year : 2022

Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case‐control studies ( SYNERGY )

Thomas Behrens
Per Gustavsson
  • Function : Author
Dario Mirabelli
  • Function : Author
Dario Consonni
  • Function : Author
Neil Caporaso
  • Function : Author
Maria Teresa Landi
  • Function : Author
John Field
  • Function : Author
Stefan Karrasch
  • Function : Author
Heinz-Erich Wichmann
  • Function : Author
Jack Siemiatycki
  • Function : Author
Marie-Elise Parent
  • Function : Author
Lorenzo Richiardi
  • Function : Author
Lorenzo Simonato
  • Function : Author
Wolfgang Ahrens
  • Function : Author
Hermann Pohlabeln
  • Function : Author
Guillermo Fernández-Tardón
  • Function : Author
David Zaridze
  • Function : Author
John Mclaughlin
  • Function : Author
Paul Demers
  • Function : Author
Beata Świątkowska
  • Function : Author
Jolanta Lissowska
  • Function : Author
Tamás Pándics
  • Function : Author
Eleonora Fabianova
  • Function : Author
Dana Mates
  • Function : Author
Vladimir Bencko
  • Function : Author
Lenka Foretova
  • Function : Author
Vladimír Janout
  • Function : Author
Paolo Boffetta
  • Function : Author
Bas Bueno-De-Mesquita
  • Function : Author
Francesco Forastiere
  • Function : Author
Kurt Straif
  • Function : Author

Abstract

There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates.
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Dates and versions

hal-03789594 , version 1 (20-12-2022)

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Thomas Behrens, Calvin Ge, Roel Vermeulen, Benjamin Kendzia, Ann Olsson, et al.. Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case‐control studies ( SYNERGY ). International Journal of Cancer, 2022, ⟨10.1002/ijc.34272⟩. ⟨hal-03789594⟩
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