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Journal Articles Nature Year : 2022

Grey wolf genomic history reveals a dual ancestry of dogs

Anders Bergström (1) , David W. G. Stanton (2) , Ulrike H. Taron , Laurent Frantz (3) , Mikkel-Holger S. Sinding (4, 5, 6) , Erik Ersmark , Saskia Pfrengle (7) , Molly Cassatt-Johnstone , Ophélie Lebrasseur (8) , Linus Girdland-Flink , Daniel M. Fernandes , Morgane Ollivier (9) , Leo Speidel (1, 10) , Shyam Gopalakrishnan (4) , Michael V. Westbury , Jazmin Ramos-Madrigal (11) , Tatiana R. Feuerborn (7) , Ella Reiter (7) , Joscha Gretzinger (7, 12) , Susanne C. Münzel (7) , Pooja Swali (1) , Nicholas J. Conard (13) , Christian Carøe (14) , James Haile (8) , Anna Linderholm (15, 16) , Semyon Androsov , Ian Barnes (17) , Chris Baumann (7) , Norbert Benecke (18) , Selina Brace (19) , Ruth F. Carden (20) , Dorothée G Drucker , Sergey Fedorov , Mihál Gasparik , Mietje Germonpré (21) , Semyon Grigoriev (22) , Pam Groves , Stefan T. Hertwig , Varvara V. Ivanova , Luc Janssens , Richard P. Jennings (23) , Aleksei K. Kasparov , Irina V. Kirillova , Islam Kurmaniyazov , Yaroslav V. Kuzmin , Pavel A. Kosintsev , Martina Lázničková-Galetová (24) , Charlotte Leduc , Pavel Nikolskiy , Marc Nussbaumer , Ludovic Orlando (25) , Alan Outram , Elena Y. Pavlova , Angela R. Perri , Małgorzat Pilot , Vladimir V. Pitulko , Valerii V. Plotnikov , Albert V. Protopopov , Mikhail Sablin , Andaine Seguin-Orlando (25) , Jan Storå , Christian Verjux , Victor F. Zaibert , Grant Zazula , Philippe Crombé , Anders J. Hansen , Eske Willerslev , Jennifer A. Leonard , Anders Götherström , Ron Pinhasi (26) , Verena J. Schuenemann , Michael Hofreiter , M. Thomas P. Gilbert , Beth Shapiro , Greger Larson , Johannes Krause (27) , Love Dalén , Pontus Skoglund (1)
Ulrike H. Taron
  • Function : Author
Erik Ersmark
  • Function : Author
Molly Cassatt-Johnstone
  • Function : Author
Linus Girdland-Flink
  • Function : Author
Daniel M. Fernandes
  • Function : Author
Michael V. Westbury
  • Function : Author
Christian Carøe
  • Function : Author
James Haile
  • Function : Author
Semyon Androsov
  • Function : Author
Dorothée G Drucker
  • Function : Author
Sergey Fedorov
  • Function : Author
Mihál Gasparik
  • Function : Author
Pam Groves
  • Function : Author
Stefan T. Hertwig
  • Function : Author
Varvara V. Ivanova
  • Function : Author
Luc Janssens
  • Function : Author
Aleksei K. Kasparov
  • Function : Author
Irina V. Kirillova
  • Function : Author
Islam Kurmaniyazov
  • Function : Author
Yaroslav V. Kuzmin
  • Function : Author
Pavel A. Kosintsev
  • Function : Author
Charlotte Leduc
  • Function : Author
Pavel Nikolskiy
  • Function : Author
Marc Nussbaumer
  • Function : Author
Alan Outram
  • Function : Author
Elena Y. Pavlova
  • Function : Author
Angela R. Perri
  • Function : Author
Małgorzat Pilot
  • Function : Author
Vladimir V. Pitulko
  • Function : Author
Valerii V. Plotnikov
  • Function : Author
Albert V. Protopopov
  • Function : Author
Mikhail Sablin
  • Function : Author
Jan Storå
  • Function : Author
Christian Verjux
  • Function : Author
Victor F. Zaibert
  • Function : Author
Grant Zazula
  • Function : Author
Philippe Crombé
  • Function : Author
Anders J. Hansen
  • Function : Author
Eske Willerslev
  • Function : Author
Jennifer A. Leonard
  • Function : Author
Anders Götherström
  • Function : Author
Verena J. Schuenemann
  • Function : Author
Michael Hofreiter
  • Function : Author
M. Thomas P. Gilbert
  • Function : Author
Beth Shapiro
  • Function : Author
Greger Larson
  • Function : Author
Love Dalén
  • Function : Author
Pontus Skoglund
  • Function : Correspondent author

Abstract

Abstract The grey wolf ( Canis lupus ) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage ( Canis familiaris ) lived 1–8 . Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located.
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Dates and versions

hal-03717833 , version 1 (20-01-2023)

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Anders Bergström, David W. G. Stanton, Ulrike H. Taron, Laurent Frantz, Mikkel-Holger S. Sinding, et al.. Grey wolf genomic history reveals a dual ancestry of dogs. Nature, 2022, ⟨10.1038/s41586-022-04824-9⟩. ⟨hal-03717833⟩
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