Formulation and evaluation of quince seeds mucilage - sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies
Résumé
Quince seed mucilage was used in a combination of sodium alginate to develop sustained-release microspheres of cefixime. Physical characterizations such as FTIR, TGA, DSC, and SEM were performed on the prepared microspheres. The swelling of microspheres was maximum at pH 7.4 and reduced at acidic pH. The average particle size ranged from 679 mu m +/-and nbsp;0.21 to 810 mu m +/-and nbsp;0.31, while the drug encapsulation efficiency range was found as 73.76 +/- 0.24-85.6 3 +/- 0.46. In vitro release profile of QSM-alginate-cefixime microspheres followed Korsmeyer-Peppas model (R-2 = 0.9732-0.9946); and release was non-Fickian as we found value of n > 1. This study reveals the benefits of QSM-alginate microspheres for the sustained release of cefixime without any toxicity and it also improved antibacterial properties. (C)and nbsp;2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
Domaines
Sciences du Vivant [q-bio]
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