Study on the synthesis, physicochemical, electrochemical properties, molecular structure and antifungal activities of the 4-pyrrolidinopyridine Mg(II) meso-tetratolylporphyrin complex - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Molecular Structure Année : 2022

Study on the synthesis, physicochemical, electrochemical properties, molecular structure and antifungal activities of the 4-pyrrolidinopyridine Mg(II) meso-tetratolylporphyrin complex

Résumé

A novel magnesium(II) metalloporphyrin namely the bis(4-pyrrolidinopyridine)[meso-tetra(p-tolyl)porphyrinato)]magnesium(II) dichloromethane desolate complex with the formula [Mg(TTP)(4-pypo)2]·CH2Cl2 (I) has been synthetized and fully characterized by UV–Vis, fluorescence, IR, 1H NMR spectroscopy and mass spectrometry. The X-ray molecular structure shows that I presents two molecules (1 and 2) [Mg1(TTP)(4-pypo)2] and [Mg2(TTP)(4-pypo)2] in the asymmetric unit while the Hirshfeld surface analysis on this hexacoordinated Mg(II) porphyrin species indicates that the crystal lattice is mainly sustained by C__H…C, C__H…Cg (Cg is the centroid of a phenyl ring) and C__H…Cl intermolecular interactions. The cyclic voltammetry data of I is also reported. The bioactivity of the H2TTP, the [Mg(TTP)] starting material and [Mg(TTP)(4-pypo)2]·CH2Cl2 (I) was evaluated in vitro, by examining their inhibitory effect against three strains of Candida viz. C. albicans, C. glabrata and C. tropicalis with MIC values in the range 2.5 to 10 µg.mL−1. The screening of the susceptibility of M. canis and T. rubrum clinical strains on the three porphyrinic derivatives is also reported.
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hal-03632831 , version 1 (27-04-2022)

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Paternité - Pas d'utilisation commerciale

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S. Jabli, S. Hrichi, R. Chaabane-Banaoues, F. Molton, F. Loiseau, et al.. Study on the synthesis, physicochemical, electrochemical properties, molecular structure and antifungal activities of the 4-pyrrolidinopyridine Mg(II) meso-tetratolylporphyrin complex. Journal of Molecular Structure, 2022, 1261, pp.132882. ⟨10.1016/j.molstruc.2022.132882⟩. ⟨hal-03632831⟩
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