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Article Dans Une Revue Journal of Molecular Structure Année : 2022

Synthesis, crystal structure study, and evaluation of antimicrobial and antibiofilm activities of a novel dihydroisoquinoline-derived

Résumé

Models of dihydroisoquinoline imine 2, oxaziridine 3 and nitrone 4 were synthesized and characterized through the mass spectrum, elemental analysis and NMR spectral studies. The crystal structure of compound 4 was determined from single crystal X-ray diffraction data. All these compounds were evaluated for their antimicrobial and antibiofilm activities, represented here with MICs values and% anti-adherence activity. Antimicrobial activity showed MICs values ranged between 0.31 and more than 2.5 mg/ml and Anti-adherence activity reached more than 75% especially with nitrone compound 4 when applied at a concentration of 0.312 mg/ml.

Domaines

Chimie
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Dates et versions

hal-03515118 , version 1 (28-03-2022)

Licence

Paternité - Pas d'utilisation commerciale

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Citer

A. Selmi, O. Kammoun, S. Mnif, Paul Mosset, M. Kammoun. Synthesis, crystal structure study, and evaluation of antimicrobial and antibiofilm activities of a novel dihydroisoquinoline-derived. Journal of Molecular Structure, 2022, 1252, pp.132190. ⟨10.1016/j.molstruc.2021.132190⟩. ⟨hal-03515118⟩
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