Perinatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Toxicology Letters Année : 2014

Perinatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice

Résumé

Glufosinate ammonium is one of the most widely used herbicides in agriculture. As is the case for most pesticides, potential adverse effects of GLA have not been studied from the perspective of developmental neurotoxicity. Early pesticides exposure may weaken the basic structure of the developing brain and cause permanent changes leading to a wide range of lifelong effects on health and/or behavior. Here we addressed the developmental impact of GLA by exposing female mice to low dose GLA during both pre- and postnatal periods and analyzed potential developmental and behavioral changes of the offspring during infancy and adulthood. A neurobehavioral test battery revealed significant effects of GLA on early reflex development, pup communication, affiliative behaviors, and preference for social olfactory cues, but emotional reactivity and emotional memory remained unaltered. These behavioral alterations showed a striking resemblance to changes seen in animal models of Autistic Spectrum Disorders (ASD). We observed brain weight abnormalities and alterations in neuroblast migration within the subventricular zone (Cf. poster Herzine et al. in the present meeting). We identified disturbances in the expression patterns of two genes implicated in autism-like deficits. Our work thus provides new data on the link between perinatal exposure to the herbicide GLA and the onset of autism-like symptoms later in life. It also raises fundamental concerns about the ability of current safety testing to assess risks of pesticide exposure during critical developmental periods.
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Dates et versions

hal-03477652 , version 1 (13-12-2021)

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Anthony Laugeray, Ameziane Herzine, Olivier Perche, Olivier Richard, Arnaud Menuet, et al.. Perinatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice. Toxicology Letters, 2014, 229, pp.S43. ⟨10.1016/j.toxlet.2014.06.191⟩. ⟨hal-03477652⟩
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