Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Neuroimage-Clinical Année : 2022

Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression

Résumé

BackgroundThe search of biomarkers in the field of depression requires easy implementable tests that are biologically rooted. Qualitative analysis of verbal fluency tests (VFT) are good candidates, but its cerebral correlates are unknown.MethodsWe collected qualitative semantic and phonemic VFT scores along with grey and white matter anatomical MRI of depressed (n = 26) and healthy controls (HC, n = 25) women. Qualitative VFT variables are the “clustering score” (i.e. the ability to produce words within subcategories) and the “switching score” (i.e. the ability to switch between clusters). The clustering and switching scores were automatically calculated using a data-driven approach. Brain measures were cortical thickness (CT) and fractional anisotropy (FA). We tested for associations between CT, FA and qualitative VFT variables within each group.ResultsPatients had reduced switching VFT scores compared to HC. Thicker cortex was associated with better switching score in semantic VFT bilaterally in the frontal (superior, rostral middle and inferior gyri), parietal (inferior parietal lobule including the supramarginal gyri), temporal (transverse and fusiform gyri) and occipital (lingual gyri) lobes in the depressed group. Positive association between FA and the switching score in semantic VFT was retrieved in depressed patients within the corpus callosum, right inferior fronto-occipital fasciculus, right superior longitudinal fasciculus extending to the anterior thalamic radiation (all p < 0.05, corrected).ConclusionTogether, these results suggest that automatic qualitative VFT scores are associated with brain anatomy and reinforce its potential use as a surrogate for depression cerebral bases.
Fichier principal
Vignette du fichier
Domain_1-s2.0-S2213158221003545-main.pdf (2.7 Mo) Télécharger le fichier
Domain_1-s2.0-S2213158221003545-mmc1.pdf (248.97 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03477309 , version 1 (30-05-2022)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Léa Domain, Murielle Guillery, Nicklas Linz, Alexandra König, Jean-Marie Batail, et al.. Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression. Neuroimage-Clinical, 2022, 33, pp.102910. ⟨10.1016/j.nicl.2021.102910⟩. ⟨hal-03477309⟩
117 Consultations
108 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More