Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Infection Année : 2021

Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France

Hélène Blanché
Marie Zins
Jean-François Deleuze
Xavier de Lamballerie

Résumé

Background The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocapsid protein (ELISA-NP) and neutralizing antibodies (SN) in 82,126 adults from a French population-based multi-cohort study. Results ELISA-S positivity was increased in 30-to 49-year-old adults (8.5%) compared to other age groups (5.6% in 20-to 29-year-olds, 2.8% in ≥ 50-year-olds). In the 3681 ELISA-S positive participants, ELISA-NP and SN positivity exhibited a U-shaped relationship with age, with a lower rate in 30-to 49-year-old adults, and was strongly associated with COVID-19-like symptoms. Conclusion Our study confirms the independent role of age and symptoms on the serologic profile of anti-SARS-CoV-2 antibodies, but the non-linear relationship with age deserves further investigation.
Fichier principal
Vignette du fichier
Carrat2021_Article_AgeCOVID-19-likeSymptomsAndSAR.pdf (683.63 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03456505 , version 1 (30-11-2021)

Identifiants

Citer

Fabrice Carrat, Nathanael Lapidus, Laetitia Ninove, Hélène Blanché, Delphine Rahib, et al.. Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France. Infection, 2021, 50 (1), pp.257-262. ⟨10.1007/s15010-021-01731-5⟩. ⟨hal-03456505⟩
117 Consultations
50 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More