Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2021

Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains

Résumé

A small library of new piperidine-triazole hybrids with 3-aryl isoxazole side chains has been designed and synthesized. Their cytotoxicity against a panel of seven cancer cell lines has been established. For the most promising compound, an IC(50) value of 3.8 μM on PUMA/Bcl-xL interaction in live cancer cells was established through BRET analysis. A rationale was proposed for these results through complete molecular modelling studies.
Fichier principal
Vignette du fichier
Murthy et al-2021-Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with.pdf (1.75 Mo) Télécharger le fichier
Murthy_1-s2.0-S0960894X2100617X-mmc1.pdf (5.24 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03414697 , version 1 (10-11-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Appala Venkata Ramana Murthy, Vennu Narendar, Nangunoori Sampath Kumar, Pasula Aparna, Anagani Kanaka Durga Bhavani, et al.. Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains. Bioorganic and Medicinal Chemistry Letters, 2021, 52, pp.128390. ⟨10.1016/j.bmcl.2021.128390⟩. ⟨hal-03414697⟩
114 Consultations
70 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More