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Article Dans Une Revue Scientific Reports Année : 2021

Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia

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Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI-citrulline, intestinal fatty acid-binding protein (I-FABP), and D-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients-50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0-26.0) vs. 23.3 μmol/L (18.3-29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58-0.78). No statistical difference was found in plasma I-FABP and plasma D-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and D-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.
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hal-03369677 , version 1 (07-10-2021)

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Alexandre Nuzzo, Kevin Guedj, Sonja Curac, Claude Hercend, Claude Bendavid, et al.. Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia. Scientific Reports, 2021, 11 (1), pp.18929. ⟨10.1038/s41598-021-98012-w⟩. ⟨hal-03369677⟩
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