Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Medicine Année : 2021

Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age

Patrick Brochard
  • Fonction : Auteur
Justine Gallet
  • Fonction : Auteur
  • PersonId : 1109978
Aude Lacourt
  • Fonction : Auteur
  • PersonId : 909333
Fleur Delva
  • Fonction : Auteur
  • PersonId : 1084406

Résumé

Objective: the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos.Methods: previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four regions of France, underwent chest CT examinations and pulmonary function testing. Industrial hygienists evaluated asbestos exposure and calculated for each subject a cumulative exposure index (CEI) to asbestos. Smoking status information was also collected in this second round of screening. Expert radiologists performed blinded independent double reading of chest CT-scans and classified interstitial lung abnormalities into: no abnormality, minor interstitial findings, interstitial findings inconsistent with UIP, possible or definite UIP. In addition, emphysema was assessed visually (none, minor: emphysema <25%, moderate: between 25 and 50% and severe: >50% of the lung). Logistic regression models adjusted for age and smoking were used to assess the relationship between interstitial lung abnormalities and occupational asbestos exposure.Results: the study population consisted of 2157 male subjects. Interstitial lung abnormalities were present in 365 (16.7%) and emphysema in 444 (20.4%). Significant positive association was found between definite or possible UIP pattern and age (OR adjusted =1.08 (95% CI: 1.02-1.13)). No association was found between interstitial abnormalities and CEI or the level of asbestos exposure.Conclusion: presence of interstitial abnormalities at HRCT was associated to aging but not to cumulative exposure index in this cohort of former workers previously occupationally exposed to asbestos.
Fichier principal
Vignette du fichier
jcm-10-03130-v2.pdf (386.77 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03341350 , version 1 (10-09-2021)

Licence

Paternité

Identifiants

Citer

Francois Laurent, Ilyes Benlala, Gael Dournes, Céline Gramond, Isabelle Thaon, et al.. Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age. Journal of Clinical Medicine, 2021, 10 (14), pp.3130. ⟨10.3390/jcm10143130⟩. ⟨hal-03341350⟩
64 Consultations
51 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More