Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with omega-Amino Fatty Acids under Hydrosilylation Conditions - Université de Rennes Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2021

Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with omega-Amino Fatty Acids under Hydrosilylation Conditions

Résumé

An efficient method for the preparation of lactams from omega-amino fatty acids under hydrosilylation is described. A variety of lactams such as pyrrolidinones, piperidinones and 2-azepanones were selectively synthesised in moderate to excellent yields (29 examples, up to 95 % isolated yields) with a good functional group tolerance. Notably, no metallic based catalyst was required to perform this transformation.
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Dates et versions

hal-03331215 , version 1 (16-09-2021)

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Satawat Tongdee, Duo Wei, Jiajun Wu, Chakkrit Netkaew, Christophe Darcel. Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with omega-Amino Fatty Acids under Hydrosilylation Conditions. European Journal of Organic Chemistry, 2021, 2021 (40), pp.5536-5539. ⟨10.1002/ejoc.202100719⟩. ⟨hal-03331215⟩
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