Additive Value of Dynamic FDOPA PET/CT for Glioma Grading - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Frontiers in Medicine Année : 2021

Additive Value of Dynamic FDOPA PET/CT for Glioma Grading

Résumé

Purpose: The aim of this study was to assess the value of the FDOPA PET kinetic parameters extracted using full kinetic analysis for tumor grading with neuronavigation-guided biopsies as reference in patients with newly-diagnosed gliomas. Methods: Fourteen patients with untreated gliomas were investigated. Twenty minutes of dynamic positron-emission tomography (PET) imaging and a 20-min static image 10 min after injection were reconstructed from a 40-min list-mode acquisition immediately after FDOPA injection. Tumors volume-of-interest (VOI) were generated based on the MRI-guided brain biopsies. Static parameters (TBRmax and TBRmean) and kinetic parameters [K1 and k2 using full kinetic analysis with the reversible single-tissue compartment model with blood volume parameter and the time-to-peak (TTP)] were extracted. Performances of each parameter for differentiating low-grade gliomas (LGG) from high-grade gliomas (HGG) were evaluated by receiver-operating characteristic analyses (area under the curve; AUC). Results: Thirty-two tumoral VOI were analyzed. K1, k2, and TTP were significantly higher for HGG than for LGG (median K1-value = 0.124 vs. 0.074 ml/ccm/min, p = 0.025, median k2-value = 0.093 vs. 0.063 min(-1), p = 0.025, and median TTP-value = 10.0 vs. 15.0 min, p = 0.025). No significant difference was observed for the static parameters. The AUC for the kinetic parameters was higher than the AUC for the static parameters (respectively, AUC(K1) = 0.787, AUC(k2) = 0.785, AUC(TTP) = 0.775, AUC(TBRmax) = 0.551, AUC(TBRmean) = 0.575), significantly compared to TBRmax (respectively, p = 0.001 for K1, p = 0.031 for k2, and p = 0.029 for TTP). Conclusion: The present study suggests an additive value of FDOPA PET/CT kinetic parameters for newly-diagnosed gliomas grading.
Fichier principal
Vignette du fichier
pdf (745.42 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03329582 , version 1 (06-05-2022)

Licence

Paternité

Identifiants

Citer

Antoine Girard, Pierre-Jean Le Reste, Alice Metais, Nibras Chaboub, Anne Devillers, et al.. Additive Value of Dynamic FDOPA PET/CT for Glioma Grading. Frontiers in Medicine, 2021, 8, pp.705996. ⟨10.3389/fmed.2021.705996⟩. ⟨hal-03329582⟩
54 Consultations
10 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More