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Article Dans Une Revue Arthritis Care and Research Année : 2022

Diagnostic performances of ultrasound evaluation of major salivary glands according to the 2019 OMERACT US scoring system

Résumé

OBJECTIVE: To evaluate the diagnostic performance of ultrasound examination of the major salivary glands (US-SG) according to the 2019 OMERACT US scoring system for Sjogren’s syndrome (SS). METHODS: This was a retrospective study based on a multicentric cohort of SS/sicca syndrome. ACR/EULAR 2016 (≥ 4 without OSS), AECG 2002 and clinician experts were considered as reference standards for SS diagnosis. An OMERACT score ≥ 2 according to 2 independent readers defined the diagnosis of SS based on US-SG assessment. Diagnostic performances and Inter-observer reproducibility of US-SG were assessed. RESULTS: Forty-two patients fulfilling the ACR/EULAR 2016 criteria for SS were compared to 30 controls with sicca syndrome. Twenty-five patients were diagnosed with SS according to US-SG evaluation, they were more frequently included in the SS group (52.5%) than in controls (10.0%) (p < 0.001). US-SG showed AUC of 0.751 (0.621-0.882) for the diagnosis of SS (ACR/EULAR 2016 classification). The inclusion of USSG in the ACR/EULAR 2016 classification improved Se (91.5% vs 89.4%) with limited decrease of Sp (96.0% vs 100%) and with an AUC of 0.975 (0.945-1.00). Similar results were observed when USSG was included in the AECG 2002 classification. Inter-observer reproducibility of the 2019 OMERACT US scoring ≥ 2 for SS diagnosis was good (k =0.73 (0.64-0.81)). Histological lymphocyte infiltration of the minor salivary glands was associated with the OMERACT grading of US-SG. CONCLUSION: This study confirms the good specificity of the 2019 OMERACT US classification of US-SG for the diagnosis of SS and its feasibility in daily practice.
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hal-03253476 , version 1 (15-06-2021)

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François Robin, Jean-David Albert, Alain Lescoat, Amélie Martel, Aleth Perdriger, et al.. Diagnostic performances of ultrasound evaluation of major salivary glands according to the 2019 OMERACT US scoring system. Arthritis Care and Research, 2022, 74 (11), pp.1924-1932. ⟨10.1002/acr.24631⟩. ⟨hal-03253476⟩
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